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BIOVAIL CONTRACT RESEARCH
(A Division of Biovail Corporation)
Biovail's state-of-the-art clinics house more than 230 beds in
several separate clinic areas, comfortably accommodating many types
of clinical studies, including:
* Large studies of up to 80 subjects
* Mixed population studies
* Segregated individual studies
* Studies with controlled substances
* Studies conducted in a varied range of products in
all major therapeutic areas
Bioanalytical Laboratory
Validated Bioanalytical Methods
| Drug |
LOQ,
ng/mL |
Technique |
| Acetaminophen |
50 |
HPLC-UV |
| Acyclovir |
10 |
HPLC-FL |
| Amitriptyline |
1 |
HPLC-UV |
| Alendronate
in urine |
1 |
LC-MS/MS |
| Atenolol
(whole blood) |
12.8 |
HPLC-FL |
| Azithromycin |
5 |
LC-MS |
| Bromazepam |
5 |
HPLC-UV |
| Bumetanide |
1 |
HPLC-FL |
| Bupropion |
1.0 |
LC-MS/MS |
|
Bupropion Erythroamino Alcohol |
2.0 |
|
|
Bupropion Threoamino Alcohol |
2.0 |
|
|
HydroxyBupropion |
1.0 |
|
| Buspirone(Human/Mice) |
0.05 |
LC-MS/MS |
|
1-(2-Pyrimidyl)Piperazine |
0.2 |
|
| Buspirone
(Rat) |
0.4 |
LC-MS/MS |
|
1-(2-Pyrimidyl)Piperazine |
1.6 |
|
| Carbamazepine |
50 |
HPLC-UV |
|
Carbamazepine-10, 11-Epoxide |
10 |
|
| Cefaclor |
200 |
HPLC-UV |
| Cefixime |
100 |
HPLC-UV |
| Cimetidine |
12.5 |
HPLC-UV |
| Citalopram |
0.25 |
HPLC-FL |
| Citalopram |
0.25 |
LC-MS/MS |
|
Demethylcitalopram |
0.05 |
|
|
Didemethylcitalopram |
0.05 |
|
| Clavulanic
Acid |
100 |
LC-MS/MS |
| Clonazepam |
0.1 |
LC-MS/MS |
| Cloxacillin |
100 |
HPLC-UV |
| Clozapine |
0.1 |
LC-MS/MS |
| Diclofenac |
5 |
HPLC-UV |
| Diflunisal |
500 |
HPLC-UV |
| Diltiazem |
3 |
HPLC-UV |
|
Desacetyldiltiazem |
1 |
|
|
& Desmethyldiltiazem |
3 |
|
| Doxazosin
(archiral) |
0.5 |
HPLC-FL |
| Doxepin |
2 |
HPLC-UV |
|
Nordoxepin |
1 |
|
| Doxycycline |
80 |
HPLC-UV |
| Enalapril/HCTZ |
0.25/2.5 |
LC-MS/MS |
|
Enalaprilat |
0.25 |
|
| Etodolac |
250 |
HPLC-UV |
| Famotidine |
5 |
HPLC-UV |
| Felodipine |
0.05 |
LC-MS/MS |
| Fexofenadine |
5 |
HPLC-FL |
| Fluvoxamine |
0.5 |
LC-MS/MS |
| Fluoxetine |
0.15 |
LC-MS |
|
Norfluoxetine |
0.15 |
|
| Gabapentin |
50 |
LC-MS/MS |
| Glipizide |
10 |
LC-MS |
| Glyburide/Glybenclamide |
5 |
HPLC-UV |
| Hydrocodone+Ibuprofen |
1.0/100 |
LC-MS/MS |
|
Hydromorphone |
1 |
|
| Hydromorphone |
0.05 |
LC-MS/MS |
| Ibuprofen |
400 |
HPLC-UV |
| Indapamide
(plasma) |
6.3 |
HPLC-UV |
| Indapamide
(whole blood) |
10 |
HPLC-UV |
| Itraconazole |
1.0 |
LC-MS/MS |
|
Hydroxy Itraconazole |
1.0 |
|
| Indomethacin |
10 |
HPLC-UV |
| Ketoprofen |
25 |
HPLC-UV |
| Lisinopril |
0.25 |
LC-MS/MS |
| Loratadine |
0.1 |
LC-MS/MS |
|
Descarboethoxyloratadine |
0.1 |
|
| Lovastatin |
0.1 |
LC-MS/MS |
|
Lovastatin Hydroxy Acid |
0.2 |
|
| Megestrol
Acetate |
1 |
LC-MS/MS |
| Metaxalone |
1000 |
HPLC-UV |
| Metformin |
25 |
HPLC-UV |
| Metoprolol |
2.5 |
HPLC-UV |
| Misoprostol/Diclofenac |
0.01/5 |
LC-MS/MS |
| Nabumetone
metabolite (6-MNA) |
500 |
HPLC-FL |
| Nadolol |
0.5 |
HPLC-FL |
| Naltrexone |
0.1 |
LC-MS/MS |
|
6 (beta) Naltrexol |
0.1 |
|
| Naproxen |
500 |
HPLC-FL |
| Nefazodone |
6.25 |
LC-MS |
|
2-Hydroxynefazodone |
1.88 |
|
|
m-Chlorophenylpiperazine |
1.25 |
|
| Nifedipine |
0.5 |
LC-MS
or LC-MS/MS |
| Nizatidine |
10 |
HPLC-UV |
|
N-Desmethylnizatidine |
5 |
|
| Nortriptyline |
1 |
HPLC-UV |
| Omeprazole |
1 |
LC-MS/MS |
| Oxaprozin |
1000 |
HPLC-UV |
| Oxycodone |
0.1 |
LC-MS/MS |
|
Oxymorphone |
0.1 |
|
| Oxycodone |
0.5 |
LC-MS/MS |
|
Noroxycodone |
0.5 |
|
|
Oxymorphone |
0.1 |
|
| Oxybutynin |
0.2 |
LC-MS/MS |
|
Desethyloxybutynin |
1.6 |
|
| Paroxetine |
0.2 |
HPLC-FL |
| Pentoxifylline |
1.3 |
LC-MS/MS |
|
Hydroxy Pentoxifylline |
4.3 |
|
|
and CPDX |
4.3 |
|
| Pentoxifylline |
5 |
HPLC-UV |
| Pindolol |
2 |
HPLC-FL |
| Prazosin |
0.1 |
HPLC-FL |
| Propranolol |
0.4 |
HPLC-FL |
|
4 -Hydroxypropranolol |
0.8 |
|
| Ranitidine |
12.6 |
HPLC-UV |
| Sertraline |
0.25 |
LC-MS/MS |
|
N-Desmethylsertraline |
0.25 |
|
| Sotalol |
10 |
HPLC-FL |
| Sulfamethoxazole |
200 |
HPLC-UV |
|
Trimethoprim |
20 |
|
| Tamoxifen |
0.25 |
LC-MS |
|
n-Desmethyltamoxifen |
0.5 |
|
| Terazosin |
0.5 |
HPLC-FL |
| Theophylline |
125 |
HPLC-UV |
| Ticlopidine |
10 |
HPLC-UV |
| Tramadol |
2.0 |
LC-MS/MS |
|
O-Desmethyltramadol |
1.0 |
|
|
O,N-di-Desmethyltramadol |
1.0 |
|
| Trazodone |
10 |
HPLC-FL |
| Valproic
acid |
924 |
HPLC-UV |
| Verapamil
(Chiral ) |
1.6 |
HPLC-FL |
|
Norverapamil R and S |
1.6 |
|
| Verapamil |
2 |
HPLC-FL |
|
Norverapamil |
2 |
HPLC-FL |
| Zolpidem |
1 |
HPLC-FL |
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