Immunoassays of psychoactive drugs including psychotomimetic drugs, narcotic drugs, and tetrahydrocannabinols and treatment methods based on the antigenic properties of protein conjugates of these drugs. These methods are based upon treating the psychoactive substances as haptens and utilizing their protein conjugates to produce antibodies to the psychoactive materials themselves. The immunoassay methods include both agglutination and agglutination-inhibition reactions. The treatment methods include treatment of both exogenous, administered drugs (such as cannabinols, LSD, heroin and morphine) and endogenous substances (such as N,N-Dimethyltryptamine and 5-Methoxy-N,N-Dimethyltryptamine, by active immunization and also passive immunization.

Claims

Having thus described the invention, what is claimed and desired to be secured by Letters Patent is:

1. A method of treating schizophrenia in a human, said method comprising administering to said human an antibody to a species which is etiological to schizophrenia.

2. The method of claim 1 wherein said species is a psychoactive indoleamine.

3. The method of claim 1 wherein said antibody comprises in vitro prepared fragments of an antibody produced in vivo in a suitable animal.

4. The method of claim 1 wherein said species is an enzyme.

5. The method of claim 4 wherein said enzyme catalyzes a reaction in the metabolism of a psychoactive indoleamine.

6. The method of claim 1 wherein said antibody comprises at least one immunologically active part of a complete antibody.

7. A method of treating a mental illness in a human, the etiology of said mental illness comprising endogenous production of a psychoactive hapten, said method comprising administering to said human an antibody to said hapten or to an enzyme which catalyzes a reaction in the metabolism of the hapten.

8. The method of claim 7 wherein said antibody comprises at least one immunologically active part of a complete antibody.
 

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