United States Patent:  5,958,461

Assignee:  Marshall University Research Corporation (Huntington, WV)

Filed:  June 20, 1997

Gelled vaginal pharmaceutical composition containing: a water-soluble bioadhesive polymer, a peroxide source and pH buffer wherein the composition has a pH between about 3.0 and about 6.0; and methods of using same.

SUMMARY OF THE INVENTION

One aspect of the present invention involves the formation of a gelled vaginal pharmaceutical composition, which comprises a water-soluble bioadhesive polymer, a peroxide source and a pH buffer wherein the composition has a pH between about 3.0 and about 6.0.

Another embodiment involves a method for maintaining or enhancing the normal protective function of vaginal flora, which comprises administering a therapeutically effective amount of a gelled vaginal pharmaceutical composition into the vaginal cavity.

A further embodiment involves a method for treating a vaginal infection, which comprises administering to the vaginal cavity a therapeutically effective amount of a vaginal pharmaceutical composition comprising a water-soluble acrylic acid polymer, an active therapeutic agent, a peroxide source and a pH buffer wherein the pH of the composition is between about 3.0 and about 6.0.

An additional embodiment involves a gelled vaginal contraceptive composition which comprises a water soluble polymer, a peroxide source, an active spermicidal agent, and buffer, wherein the composition has a pH between about 3.0 and about 6.0.

Claim 1 of 7 Claims

1. A gelled vaginal contraceptive composition, which comprises:

a water soluble polymer consisting of an acrylic acid modified polymer, a peroxide source consisting of hydrogen peroxide, an active spermicidal agent, and a pH buffer, wherein the composition has a pH between about 3.0 and about 6.0.

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