Title:  Adhesive medical composition with sustained medicament releasbility and process for preparing same

United States Patent:  6,146,654

Assignee:  Alcare Co., Ltd. (Tokyo, JP)

Filed:  June 6, 1997

Foreign Application Priority Data:  Jun 10, 1996[JP] (8-168725)

The present invention is directed to a blending medical composition with a sustained medicament releasability, which can reduce the amount of medicament required to be contained in the composition, and can control the amount of medicament to be released according to a degree of moisture present at a moist application site. The present composition includes a medicament-containing hydrophilic composition including a water-soluble or water-dispersible hydrophilic composition and a medicament, dispersed and blended into a binding composition capable of retaining the medicament-containing hydrophilic composition.

SUMMARY OF THE INVENTION

The present invention has been established to overcome the above-mentioned disadvantages of the prior art and to provide a blending medical composition with a sustained medicament releasability, which contains a decreased amount of a medicament and can control a medicament releasing rate by a moisture degree when applied at moist sites.

According to one aspect of the present invention, a medicament-containing hydrophilic composition comprising a water-soluble or water-dispersible hydrophilic composition and a medicament is dispersed and blended into a binding composition capable of retaining the medicament-containing hydrophilic composition within.

According to another aspect of the present invention, the medicament-containing hydrophilic composition with sustained medicament releasability is prepared by uniformly mixing a hydrophilic composition and a medicament with a moisture or a water soluble binder in either powdered or moist form, and dispersing and blending the medicament-containing hydrophilic composition into a binding composition.

In use, the present blending medical composition will release the medicament from the hydrophilic composition upon absorption of moisture, humor, etc. from living bodies, and thus the medicament is effectively releasable from the hydrophilic composition according to the degree of moisture, humor, etc. present at sites to which the blending medical composition is applied. That is, the contained medicament can be very efficiently utilized, resulting in saving of the amount of medicament to be contained in the blending medical composition and also in eliminating of a side effect risk due to an action of the medicament, when contained in excess, for a short time. Furthermore, no pharmacological action takes place at normal sites where moisture, humor, etc. exude and secrete less, causing no side effect at all. Thus, the present blending medical composition can be safely used with a remarkable cost reduction effect.

Claim 1 of 18 Claims

What is claimed is:

1. An adhesive composition with a sustained medicament releasability, comprised of a medicament, a hydrophilic composition, and a binding composition capable of retaining the hydrophilic composition, said hydrophilic composition being soluble in water, humor and exudate, and being selected from the group consisting of natural hydrophilic compositions, semi-synthetic hydrophilic compositions and synthetic hydrophilic compositions and mixtures thereof, said medicament being dispersed and blended into said hydrophilic composition to form a medicament-containing hydrophilic composition, and particles of said medicament-containing hydrophilic composition being dispersed in said binding composition, wherein a portion of said medicament-containing hydrophilic composition particles is capable of being exposed to an outside surface of said binding composition by dissolution, separation or decomposition of said medicament-containing hydrophilic composition particles by absorption of a water-containing liquid, to release said medicament from said portion of said medicament-containing hydrophilic composition particles.

____________________________________________
If you want to learn more about this patent, please go directly to the U.S. Patent and Trademark Office Web site to access the full patent.