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Title:  Method for treating dystonia with botulinum toxin types C to G

United States Patent:  6,319,505

Inventors:  Aoki; K. Roger (Laguna Hill, CA); Grayston; Michael W. (Irvine, CA); Carlson; Steven R. (Laguna Niguel, CA); Leon; Judith M. (Laguna Niguel, CA)

Assignee:  Allergan Sales, Inc. (Irvine, CA)

Appl. No.:  490755

Filed:  January 24, 2000

Abstract

A method and composition for treating a patient suffering from a disease, disorder or condition and associated pain include the administration to the patient of a therapeutically effective amount of a neurotoxin selected from a group consisting of Botulinum toxin types A, B, C, D, E, F and G.

SUMMARY OF THE INVENTION

The present invention provides a method for relieving pain, associated with muscle contractions, a composition and a method of treating conditions such as cholinergic controlled secretions including excessive sweating, lacrimation and mucus secretions and a method for treating smooth muscle disorders including, but not limited to, spasms in the sphincter of the cardiovascular arteriole, gastrointestinal system, urinary, gall bladder and rectum, which method comprises administering to the patient suffering from said disorder or condition a therapeutically effective amount of Botulinum toxin selected from the group consisting of Botulinum toxin types B, C, D, E, F and G.

Each serotype of Botulinum toxin has been identified as immunologically different proteins through the use of specific antibodies. For example, if the antibody (antitoxin) recognizes, that is, neutralizes the biological activity of, for example, type A it will not recognize types B,C,D, E, F or G.

While all of the Botulinum toxins appear to be zinc endopeptidases, the mechanism of action of different serotypes, for example, A and E within the neuron appear to be different than that of Type B. In addition, the neuronal surface "receptor" for the toxin appears to be different for the serotypes.

In the area of use of the Botulinum toxins in accordance with the present invention with regard to organ systems which involve the release of neurotransmitter, it is expected to introduce the toxins A, B, C, D, E, F, and G directly by local injections.

Claim 1 of 3 Claims

What is claimed is:

1. A method for treating tardive dyskinesia, the method comprising the step of administering to a patient suffering from tardive dyskinesia an effective amount of a botulinum toxin selected from a group consisting of the botulinum toxin types C, E, and G, thereby alleviating a symptom of the tardive dyskinesia.

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If you want to learn more about this patent, please go directly to the U.S. Patent and Trademark Office Web site to access the full patent.

 

 

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