Title: Method for improving delivery of tyrosine
United States Patent: 6,294,579
Inventors: Carnazzo; Joseph W. (P.O. Box 150, Boys Town, NE
Appl. No.: 415808
Filed: October 11, 1999
The base compound for practicing the present invention is L-tyrosine
effervescent powder, granules or tablet. Soluble effervescent powders,
granules and tablets are prepared by blending and/or compression and
contain, in addition to active ingredients mixtures of acids (citric acid,
tartaric acid) and sodium bicarbonate, which release carbon dioxide when
dissolved in water. They are intended to be dissolved or dispersed in
water before administration. Effervescent powders, granules and tablets
should be stored in tightly closed containers or moisture-proof packs,
labeled to indicate that they are not to be swallowed directly.
DESCRIPTION OF THE PREFERRED EMBODIMENT
The inventor has discovered that tyrosine may be uniformly and accurately
dispensed when completely dissolved and dispersed in liquid. More
specifically, the tyrosine has been created in the form of an effervescent
in tablet or particulate form which increases the pH of water to thereby
increase the solubility of the tyrosine in the liquid.
L-tyrosine and N-acetyl tyrosine, as used in the prior art, do not readily
dissolve in water or other neutral pH liquids. The combination of tyrosine
and other chemicals to create an effervescent which, when combined with a
proper measure of water, creates a liquid having an alkaline pH, making
the tyrosine much more soluble in the liquid. The increase in solubility
allows for more uniform absorption of the tyrosine after ingestion.
In addition, because the tyrosine is packaged in either tablet or
premeasured particulate form, a precise amount of the compound is
ingested. The prior art bulk powder form required the consumer to measure
the proper amount of the product and dissolve the product in water. The
precision of such measurement is uncertain. Furthermore, because prior art
formulations of tyrosine required dissolution of tyrosine in a neutral pH
liquid, non-uniform amounts of the tyrosine supplements are commonly
undissolved and subsequently not ingested by the consumer. The result is
non-uniform dosages and ingestion at non-uniform rates.
The use of a pre-measured effervescent assures complete dissolution and
dispersal of the tyrosine and uniform rates of ingestion of the same.
These goals are achieved by virtue of increasing the pH of the liquid and
the agitation provided by the effervescence of the compound. The soluble
effervescent will contain a mixture of acids, bicarbonates, and other
agents which release carbon dioxide when dissolved in water.
The chemical formula for tyrosine is C9 H11 NO3,
and has a molecular weight of 181.19. Tyrosine is a dietary amino acid. In
addition to its value as an energy substrate and in protein synthesis, it
is a precursor to numerous biogenic amines and neurotransmitters.
Previously, tyrosine's use has been limited by its relative insolubility
in water and susceptibility to stomach acid destruction. The use of
effervescent technology, therefore, is employed to alter the pH of the
water, giving tyrosine greater solubility in water and buffering stomach
acid to limit tyrosine destruction.
The method of the present invention relies upon the combination of
tyrosine with an effervescent to create an alkaline solution which is
ingested by the consumer. The effervescent raises the pH to form an
alkaline solution, whereby the tyrosine will uniformly dissolve and
completely disperse in solution. In its preferred form, the invention
includes a soluble effervescent containing tyrosine, at least one acid,
and at least one bicarbonate for releasing carbon dioxide when dissolved
in a neutral pH liquid, such as water. In the most preferred form of the
invention, L-tyrosine or N-acetyl tyrosine is the type of tyrosine that is
The effervescent ingredients preferably utilize a mixture of acids,
including citric acid and tartaric acid. Sodium bicarbonate or potassium
bicarbonate may be utilized for the release of carbon dioxide. In
addition, starch, flavoring agents, and lubricants for tablet compression
are also utilized in the effervescent tablet. While the effervescent is
preferably in the form of a tablet, it may also be utilized in a
particulate form. The effervescent must be stored in a sealed container or
other moisture-proof package, since water or other liquids will activate
the effervescent. This also allows for a method of premeasuring the
The effervescents are not to be swallowed directly, since they release
carbon dioxide as they dissolve. Thus, the initial step in the method of
the invention is to open the moisture-proof package containing the
effervescent and dispense it into a container of water or other pH neutral
liquid. Once the effervescent tyrosine has been dissolved and dispersed,
the solution should be ingested immediately.
Claim 1 of 19 Claims
1. A method of promoting delivery of tyrosine supplementation into a human
body, comprising the steps of:
dispensing a combination of an effervescent and a predetermined amount of
tyrosine into a neutral pH liquid;
dissolving the combination substantially in the liquid; and
a human ingesting the liquid.
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