Pharm/Biotech
Resources

Outsourcing Guide

Cont. Education

Software/Reports

Training Courses

Web Seminars

Jobs

Buyer's Guide

Home Page

Pharm Patents /
Licensing

Pharm News

Federal Register

Pharm Stocks

FDA Links

FDA Warning Letters

FDA Doc/cGMP

Pharm/Biotech Events

Consultants

Advertiser Info

Newsletter Subscription

Web Links

Suggestions

Site Map
 

 

 

 

Title:  Learning and short term memory defects with Neurofibromatosis 1 (NF1) expression

United States Patent:  6,365,126

Inventors:  Zhong; Yi (Huntington, NY); Guo; Hui-Fu (Huntington, NY); Tong; Jiayuan (Cold Spring Harbor, NY)

Assignee:  Cold Spring Harbor Laboratory (Cold Spring Harbor, NY)

Appl. No.:  510791

Filed:  February 23, 2000

Abstract

The present invention provides methods for treating learning and short term memory defects associated with a defect in the NF1 protein. The present invention also provides methods for screening a pharmaceutical agent for its ability to treat learning and short term memory defects associated with a defect in the NF1 protein.

SUMMARY OF THE INVENTION

The present invention relates to methods of treating a learning or short term memory defect associated with a defect in the Neurofibromatosis 1 (NF1) protein in an animal (particularly a human or other mammal or vertebrate) in need thereof. The NF1 protein defect is either a diminution in the amount of NF1 protein produced, a diminution in the activity or action of the NF1 protein produced or both a diminution in amount and activity or action of NF1 protein. In one embodiment, the method comprises administering to an animal with a learning or short term memory defect associated with a defect in the NF1 protein a NF1 compound such as exogenous NF1, NF1 analog, NF1-like moleculeogically active NF1 fragment or NF1 fusion protein. In a second embodiment, the method comprises administering to an animal with a learning or short term memory defect associated with a defect in the NF1 protein a nucleic acid sequence encoding exogenous NF1, NF1 analog, NF1-like molecule, biologically active NF1 fragment or NF1 fusion protein. In a third embodiment, the method comprises administering to an animal with a learning or short term memory defect associated with a defect in the NF1 protein an effective amount of a pharmaceutical agent that stimulates cyclic AMP formation in the same manner as NF1. In a fourth embodiment, the method comprises administering to an animal with a learning or short term memory defect associated with a defect in the NF1 protein a pharmaceutical agent that activates protein kinase A (PKA) activity in the same manner as NF1.

The present invention also relates to methods for screening a pharmaceutical agent for its ability to treat a short term memory defect associated with a defect in the NF1 protein in an animal (particularly a human or other mammal or vertebrate) in need thereof. The method comprises (a) administering a pharmaceutical agent to an animal with a short term memory defect associated with a defect in the NF1 protein; (b) training the animal under conditions appropriate to produce short term memory formation in the animal; (c) assessing short term memory formation in the animal trained in step (b); and (d) comparing short term memory formation assessed in step (c) with short term memory formation produced in the control animal to which said pharmaceutical agent has not been administered. If the short term memory formation assessed in the animal treated with the pharmaceutical agent is greater than the short term memory formation assessed in the control animal, the pharmaceutical agent is identified as one having the ability to treat a short term memory defect associated with a defect in the NF1 protein.

The invention further relates to methods for screening a pharmaceutical agent for its ability to treat a learning defect associated with a defect in the NF1 protein in an animal (particularly a human or other mammal or vertebrate) in need thereof The method comprises (a) administering a pharmaceutical agent to an animal with a learning defect associated with a defect in the NF1 protein; (b) training the animal under conditions appropriate for learning by the animal; (c) assessing learning ability in the animal trained in step (b); and (d) comparing learning ability assessed (c) with learning ability in the control animal to which said pharmaceutical agent has not been administered. If the learning ability assessed in the treated with the pharmaceutical agent is greater than the learning ability assessed in the control animal, the pharmaceutical agent is identified as one having the ability to treat a learning defect associated with a defect in the NF1 protein.

Claim 1 of 8 Claims

What is claimed is:

1. A method for screening a pharmaceutical agent for its ability to treat a short term memory defect in an animal, wherein the short term memory defect is associated with a defect in the Neurofibromatosis 1 protein, comprising:

a) administering said pharmaceutical agent to an animal with a short term memory defect associated with a defect in the Neurofibromatosis 1 protein;

b) training said animal treated in step a) under conditions appropriate to produce short term memory formation in said animal;

c) assessing short term memory formation in said animal trained in step b); and

d) comparing short term memory formation assessed in step c) with short term memory formation produced by the training protocol of step b) in a control animal to which said pharmaceutical agent has not been administered, wherein the pharmaceutical agent is identified as one having the ability to treat said short term memory defect in said animal if short term memory formation assessed in step c) is greater than short term memory formation produced in said control animal.


____________________________________________
If you want to learn more about this patent, please go directly to the U.S. Patent and Trademark Office Web site to access the full patent.

 

 

[ Outsourcing Guide ] [ Cont. Education ] [ Software/Reports ] [ Training Courses ]
[ Web Seminars ] [ Jobs ] [ Consultants ] [ Buyer's Guide ] [ Advertiser Info ]

[ Home ] [ Pharm Patents / Licensing ] [ Pharm News ] [ Federal Register ]
[ Pharm Stocks ] [ FDA Links ] [ FDA Warning Letters ] [ FDA Doc/cGMP ]
[ Pharm/Biotech Events ] [ Newsletter Subscription ] [ Web Links ] [ Suggestions ]
[ Site Map ]