Title:  Methods for treating alopecia

United States Patent:  6,376,557

Appl. No.:  526921

Methods and compositions for the treatment of alopecia and the transdermal delivery of hair growth promoting agents. The compositions are formulated to be applied topically, preferably in the form of aqueous emulsions. The compositions may further include a variety of adjuvants to enhance the stability and effectiveness thereof.

SUMMARY OF THE INVENTION

The present invention specifically addresses and alleviates the aforementioned deficiencies in the art. Specifically, the present invention is directed to compositions and methods useful for promoting hair growth when applied to an area of skin that is afflicted with alopecia, as well as compositions and methods useful in transdermally delivering hair growth promoting agents applied topically to the areas of skin afflicted with alopecia.

In a first preferred embodiment, the composition of the present invention comprises a suspension or aqueous emulsion having ancrine present in an amount from about 0.5% to about 4.0% by weight, capilectine present in an amount from about 1.2% to about 8.0% by weight, capisome present in an amount from about 1.2% to about 8.0% by weight, capigen present in an amount from about 1.2% to about 8.0% by weight, and capillisil present in an amount from about 3.0% to about 4.0% by weight, which is formulated to be applied topically.

In a second embodiment, the composition of the present invention comprises a suspension or aqueous emulsion having sulfur present from about 0.4% to about 5.0% by weight, mahanimba present from about 0.4% to about 5.0% by weight, malkagni present from about 0.3% to about 4.0% by weight, and Fitopur B present from about 1.2% to about 8.0% by weight, which is formulated to be applied topically.

In a third embodiment, the composition of the present invention comprises a suspension or aqueous emulsion having an mo le present from about 1.2% to about 8.0% by weight, biao beng li present from about 1.2% to about 8.0% by weight, qing hao present from about 1.2% to about 8.0% by weight, kui li present from about 1.2% to about 8.0% by weight, and enzymatic hydrolysate of casein present from about 0.3% to about 4.0% by weight, which is formulated to be applied topically.

In a fourth embodiment, the composition of the present invention comprises a suspension of aqueous emulsion having seamollient present at about 49.02% by weight, capilectine present at about 4.901% by weight, capigen present at about 4.901% by weight, ancrine present at about 2.45% by weight, Fitopur B present at about 4.901% by weight, sulfur present at about 3.431% by weight, capisome present at about 4.901% by weight, mahanimba present at about 3.431% by weight, capillisil present at about 1.961% by weight, malkagni present at about 1.961% by weight, kui li present at about 4.901% by weight, an mo le present at about 4.901%, biao beng li present at about 4.901% by weight, qing hao present at about 4.901% by weight, enzymatic hydrolysate of casein present at about 1.961% by weight, microreservoir present at about 1.471% by weight, and honeysuckle present at about 0.1% by weight, which is formulated to be applied topically.

Each of the aforementioned compositions of the preferred embodiments may further be useful for supporting and transdermally administering a pharmaceutically effective amount of hair growth promoter agent, such as minoxidil or propecia, insofar as such compositions attain superior transdermal penetration.

Claim 1 of 8 Claims

What is claimed is:

1. A method for treating hair loss resulting from alopecia which comprises topically applying to the skin at a desired area for hair regrowth an effective amount of a composition comprising a complex comprising octyl butyrate and glutamine-containing peptides, a lectin derived from Solanum tuberosum, a liposome with a mean vesicle size of between 100 and 150 nm comprising homotaurine, a bacterial filtrate from enterobacteria that contains high levels of peptides and methionine and cystine, and marine sulfomucopolysaccharides, a complex comprising homotaurine, a bacterial filtrate, and sulfomucopolysaccharides, and a 20% solution of dimethylsilanediol salicylate in butylene glycol with triethanolamine.

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