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Title:  Functional improvements in Fahr disease

United States Patent:  6,432,413

Issued:  August 13, 2002

Inventors:  Loeb; Jeffrey A. (Beverly Hills, MI)

Assignee:  Wayne State University (Detroit, MI)

Appl. No.:  260376

Filed:  March 1, 1999

Abstract

The invention provides methods of treating diseases of the central and peripheral nervous systems that are associated with abnormal calcifications within the nervous system, such as Fahr disease. These methods involve administration of bisphosphonates, such as disodium etidronate, to patients.

SUMMARY OF THE INVENTION

I have found that a class of drugs, called bisphosphonates, and the specific drug, disodium etidronate, are useful therapeutic agents for diseases of the human central and peripheral nervous systems that are associated with abnormal calcifications within the nervous system.

Accordingly, the invention provides methods of treating a patient having a disease of the nervous system characterized by abnormal calcification, by administering a bisphosphonate the patient. Treatment according to the methods of the invention results in improvement of a symptom(s) of a treated patient.

Patients that can be treated using the methods of the invention include those at all stages of development of a disease of the nervous system characterized by calcification within the nervous system. For example, treatment of an older patient with Fahr disease is described in detail below. Treatment of younger, less disabled patients with this disorder offers an alternative, more favorable course to an otherwise devastating neurologic disease.

An example of a bisphosphonate that can be used in the methods of the invention is disodium etidronate, which can be administered, for example, orally in an amount between 5-20 mg/kg/day (e.g., 10-15 mg/kg/day). Other bisphosphonates are known in the art, and can be used in the methods of the invention. For example, pamidronate, risedronate, ibandronate, olpadronate, incadronate, neridronate, tiludronate, can be used, and proper modes of administration (e.g., oral or intravenous infusion) and dosages of these drugs are known to those of skill in the art. Administration of combinations of these drugs can also be carried out.

In the methods of the invention, bisphosphonates are used to treat diseases of the nervous system in which calcifications occur within the nervous system. The mechanism of action of these agents in treating these diseases is to prevent the further growth of calcifications, and to reduce neurological symptoms related to the calcifications. Used in this fashion, bisphosphonates improve neurological function, reduce seizures, and improve abnormal behaviors.

An example of a particular disease that can be treated by the methods of the invention is Fahr disease, which is characterized by idiopathic cerebral calcification of the basal ganglia. Other examples of diseases of the nervous system that can be treated with bisphosphonates according to the invention are as follows: post-radiation-induced calcifications of the brain; post-stroke/hypoxemic calcifications; calcified brain tumors, primary and metastatic; neurocysticercosis; human immunodeficiency virus (HIV)-induced calcifications of the brain; cytomegalovirus infection; cryptococcosis of the central nervous system; other post-infectious calcifications of the brain (e.g., as is found in tuberculosis and toxoplasmosis); metabolic disease-induced cerebral calcification; endocrine disease-induced cerebral calcification (hypoparathyroidism, etc.); celiac disease; mitochondrial encephalomyopathies; subdural hematoma with calcifications; other seizure disorders associated with cerebral calcifications; arteriovenous malformations of the brain; cerebral lupus and other forms of vasculitis associated with cerebral calcifications; and presenile dementia with associated cerebral calcifications.

Claim 1 of 4 Claims

What is claimed is:

1. A method of treating a patient having a disease of the central nervous system that is characterized by the existence of abnormal calcification in the nervous system, wherein said disease is Fahr disease, said method comprising administering a bisphosphonate to said patient.
 


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If you want to learn more about this patent, please go directly to the U.S. Patent and Trademark Office Web site to access the full patent.

 

 

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