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Title:  Method for the treatment of lymphedema using guaifenesin

United States Patent:  6,436,448

Issued:  August 20, 2002

Inventors:  Yue; Samuel K. (Edina, MN)

Assignee:  Sky BioHealth Solutions, Inc. (Eden Prairie, MN)

Appl. No.:  891136

Filed:  June 25, 2001

Abstract

A novel method for preventing and treating lymphedema and for inducing weight-loss in a patient having an elevated protein concentration in the patient's by administering a therapeutically effective amount of guaifenesin or its analog to the patient. In one embodiment, the method further includes administering in the patient's diet an enzyme supplement chosen to increase the ability of the patient's gastrointestinal tract to digest food and administering to the patient an effective amount of relaxin hormone.

SUMMARY OF THE INVENTION

The present invention is based upon the recognition that a relationship exists between the porosity (altered permeability or changed selectivity) of a person's gastrointestinal tract ("GI tract") and its diseased ability to absorb partially-digested food (macronutrients, in the form of partially digested proteins or large clumps of amino acid) to the accumulation of high protein fluid in a patient's tissues resulting in weight gain and lymphedema.

Accordingly the ideal treatment for this type of lymphedema comprises: (1) restoring the selectivity or altered permeability of the mucosa within the linings of the GI tract, thus, reducing its ability to absorb partially digested proteins; and (2) treating the previously accumulated high protein edema or lymphedema.

In accordance with one aspect of the invention it has been surprisingly found that guaifenesin is useful in reducing the accumulation of fluid in a patient's tissue and in the treatment of lymphedema.

In one method of the invention, the accumulation of fluids in the tissue of a patient having such accumulation is reduced by administering to the patient a therapeutically effective amount of guaifenesin or one of its pharmaceutically acceptable derivatives. In one embodiment of the method, the amount administered is about 600 mg to about 4000 mg per day.

In one preferred embodiment of the invention, the guaifenesin or its pharmaceutically acceptable derivative is administered to the patient in two different dosage forms, one dosage form being a short acting form and the other being a long acting form. The short acting dosage is preferably about 200-600 mgs and the long acting form is preferably about 200-600 mgs. The two forms are desirably administered to the patient once or twice a day so that a sustained level of guaifenesin or its pharmaceutically acceptable derivative may be obtained in the blood stream sufficient for the lymphatic diuresis to occur.

In other embodiments of the invention, the guaifenesin or its pharmaceutically acceptable derivative may be administered to the patient in more than one dose of a short acting dosage form or in different combinations of short acting doses with long acting doses. Some reduction of fluid accumulation will be seen with the administration of guaifenesin in the amounts described herein in most patients, however, the dosage regime should be optimized for each patient.

Another embodiment of the invention is a method for inducing weight loss in patients having accumulated fluid in their tissue comprising administering an effective amount of guaifenesin or one of its pharmaceutically acceptable derivatives to a patient to cause a reduction in the amount of the accumulated fluid and weight loss.

Yet another embodiment of the invention is a method for treating and preventing lymphedema comprising the steps of: a) using guaifenesin or one of its pharmaceutically acceptable derivatives to reduce accumulated high protein fluid in a patient; b) including in the patient's diet, enzyme supplements chosen to increase the ability of the patient's gastrointestinal tract to digest food; and c) administering to the patient an effective amount of relaxin and its related hormones to induce production of new collagen to repair the mucosa and restore the selectivity of the gastrointestinal tract.

Claim 1 of 17 Claims

What is claimed is:

1. A method for treating lymphedema in a patient comprising administering a therapeutically effective amount of guaifenesin to the patient in two different dosage forms.
 


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If you want to learn more about this patent, please go directly to the U.S. Patent and Trademark Office Web site to access the full patent.

 

 

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