Title: Semaphorin-specific antibodies
United States Patent: 6,344,544Inventors: Goodman; Corey S. (Berkeley, CA); Kolodkin; Alex L. (Berkeley, CA); Matthes; David (Berkeley, CA); Bentley; David R. (Berkeley, CA); O'Connor; Timothy (Berkeley, CA)
Assignee: The Regents of the University of California (Oakland, CA)Appl. No.: 060610
Filed: April 15, 1998
A novel class of proteins, semaphorins, nucleic acids encoding semaphorins, semaphorin peptides, and methods of using semaphorins and semaphorin-encoding nucleic acids are disclosed. Semaphorin peptides and receptor agonists and antagonists provide potent modulators of nerve cell growth and regeneration. The invention provides pharmaceutical compositions, methods for screening chemical libraries for regulators of cell growth/differentiation; semaphorin gene-derived nucleic acids for use in genetic mapping, as probes for related genes, and as diagnostic reagents for genetic neurological disease; specific cellular and animal systems for the development of neurological disease therapy.
SUMMARY OF THE INVENTION
A novel class of proteins, semaphorins, nucleic acids encoding semaphorins,
and methods of using semaphorins and semaphorin-encoding nucleic acids are
disclosed. Semaphorins include the first known family of human proteins
which function as growth cone inhibitors and a family of proteins involved
in viral, particularly pox viral, pathogenesis and oncogenesis. Families
of semaphorin-specific receptors, including receptors found on nerve
growth cones and immune cells are also disclosed.
Claim 1 of 1 Claim
What is claimed is: