Title: Method of preparing and using isoflavones for the
treatment of alcoholism
United States Patent: 6,399,072
Inventors: Empie; Mark (Forsyth, IL); Gugger; Eric (Latham,
Assignee: Archer Daniels Midland Company (Decatur, IL)
Appl. No.: 615152
Filed: July 13, 2000
A composition is prepared by extracting phytochemicals from plant
matter for treatment of alcohol dependency. This composition is enriched
preferably with two or more fractions of plant matter, namely: isoflavones,
lignans, saponins, sapogenins, catechins and phenolic acids. Soy is the
preferred source of these chemicals; however, other plants may also be
used, such as wheat, psyllium, rice, oats, red clover, kudzu, alfalfa,
flax, and cocoa. The composition is a dietary supplement for treatment of
alcoholism. The isoflavone may be any in a group including malonyl,
acetyl, glucoside, and aglycone. The composition is in a concentrated form
to be delivered in an easy to consume dosage, such as a pill, tablet,
liquid, capsule, or a food supplement including a health bars.
DETAILED DESCRIPTION OF THE INVENTION
The improved composition is obtained by fractionating a plant source high
in isoflavones, lignans and other phytochemicals such as defatted soybean
flakes, soy molasses, soy whey, red clover, alfalfa, flax, cocoa, tea, or
kudzu root. These may be fractionated along or in combination with these
other plants known to be high in the various isoflavones, lignans,
saponins, catechins and phenolic acids. The fractionation results in
substantially removing water, carbohydrates, proteins, and lipids from the
source material. The fractionation method may be preferably that disclosed
in U.S. Pat. Nos. 5,702,752; 6,017,555; 6,033,714; or 4,428,876, or an
extraction using ethyl acetate or n-butanol may be used. U.S. Pat. Nos.
5,702,752; 6,017,555; 6,033,714 is assigned to the assignee of this
Other extraction processes, which may be used alone or in combination,
include differential solubility, distillation, solvent extraction,
adsorptive means, differential molecular filtration and precipitation.
The preferred composition is an improvement over known commercial
materials regarding the amount of phytochemicals per gram of substance and
the amounts of different phytochemicals present which affect physiologic
These natural substances have been consumed in food sources for long
periods of time and more closely relate to the substances consumed which
provide the basis for the epidemiological evidence for health benefits.
Additional benefits may be derived from improved physical properties
relative to phytochemicals chemically modified from their original food
The resulting composition is expected to comprise in a preferred form:
between 5% and 95% isoflavones, between 0% and 70% lignans, and between 2%
and 70% saponins and sapogenins. In a more preferred form, the composition
will be extracted from soy. In another preferred form, the composition
will contain a ratio of (saponins plus saponogenins) to isoflavones from
1:100 to 100:1, with the isoflavones consisting predominantly of naturally
occurring derivatives of genistein and/or its precursor biochanin A and
daidzein and/or its precursor formononetin, with a ratio of the genistein
derivatives to daidzein derivatives from 100:1 to 1:100. Preferably, the
isoflavones are predominantly glycosylated derivatives.
The composition's ratios may be readily varied by changing the plant
source or by combining several plant sources for extraction. Thus, as
further study shows which phytochemical combinations are more efficacious
for certain health effects, the particular composition will also vary.
It is known that isoflavones, lignans, and saponinst can be used
advantageously to treat or prevent various cancers, including breast
cancer, prostate cancer, skin cancer, and colon cancer.
It is believed that the improved composition will provide increased
benefits in the form of chemoprevention. Recent experiments appear to
confirm this belief.
Claim 1 of 10 Claims
What is claimed is:
1. A composition for treatment of medical conditions resulting from
alcohol dependency involving the brain and nerves, said composition being
made from a plant matter in which the composition is a medicament enriched
in at least two of the phytochemicals selected from the group consisting
of isoflavones, lignans, saponins, catechins and phenolic acids, said
medicament having an effective amount of phytochemicals selected on a
basis of a therapeutic treatment for alcohol dependency.
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