Title: Method of preparing and using compositions
extracted from vegetable matter for the treatment of neurological
United States Patent: 6,509,381
Issued: January 21, 2003
Inventors: Empie; Mark (Forsyth, IL); Gugger; Eric (Latham,
Assignee: Archer Daniels Midland Company (Decatur, IL)
Appl. No.: 136158
Filed: May 1, 2002
A composition is prepared by extracting and isolating phytochemical
fractions from plant matter for treatment for neurological conditions and
especially for migraine headaches, inflammations, dementia, and Alzheimer's
Disease. The composition is enriched, preferably with two or more different
fractions, namely: isoflavones, lignans, saponins and saponogenins,
catechins, and phenolic acids. The two selected fractions are different from
each other and are combined specifically to form a composition to treat a
neurological condition. Soy is the preferred source of these phytochemicals;
however, other plants may also be used, such as wheat, psyllium, rice, oats,
red clover, kudzu, alfalfa, flax, and cocoa. The composition may be
delivered in an easy to use or consume form, such as cream, pills, tablets,
capsules, pellets, dry powder, health bars, food ingredients and
supplements, soft gels, and the like.
SUMMARY OF THE INVENTION
An object of this invention is to provide a convenient way for individuals
to consume isoflavones, lignans, saponins, catechins and/or phenolic
acids, either as a nutritional supplement or as an ingredient in a more
traditional type of food.
An other object of this invention is to provide an optimized extract
composition of phytochemicals which is in sufficient concentration to be
delivered in an easy to consume dosasge such as a pill, tablet, capsule,
liquid or ingredient in a food.
Yet another object of this invention is to prepare the phytochemical
extract to be delivered as a topical application in a cream or lotion. In
this form, the isoflavones, lignans, saponins, catechins and/or phenolic
acids are dispersed and suspended in a suitable liquid or gel matrix to
render a stable cream or lotion as the delivery vehicle.
A further object of this invention is to provide an extract concentrate
which is closely similar in chemical composition to the chemical entities
found in the natural plant source.
In keeping with this aspect of the invention, the isoflavones, lignans,
saponins, catechins and/or phenolic acids are extracted from a suitable
vegetable source to render a composition which is substantially more
concentrated than the original material and by more than 5 times in one or
more of the desired bioactive components.
This extract may be used alone or combined with one or more other plant
extracts to produce the optimized composition. Further, this extract
composition may be formulated with one or more other dietary nutrients,
such as vitamins, minerals, amino acids, etc., to provide a nutritional
supplement further optimized for a desired health effect. All these
ingredients may be combined with necessary binders, excipients,
preservatives, colors and the like known to those in the industry in order
to produce a suitable tablet, capsule, pill, liquid, cream, powder or food
These phytochemicals may be packaged and provided in final form by means
known to the supplements and food ingredient industries. The materials are
intended to provide health and well-being benefits.
DETAILED DESCRIPTION OF THE INVENTION
The improved composition is obtained by fractionating a plant source high
in isoflavones, lignans and other phytochemicals such as defatted soybean
flakes, soy molasses, soy whey, red clover, alfalfa, flax, cocoa, tea, or
kudzu root. These may be fractionated along or in combination with these
other plants known to be high in the various isoflavones, lignans,
saponins, catechins and phenolic acids. The fractionation results in
substantially removing water, carbohydrates, proteins, and lipids from the
source material. The fractionation method may be preferably that disclosed
in co-pending U.S. Pat. No. 5,702,752 or U.S. Pat. No. 4,428,876, or an
extraction using ethyl acetate or n-butanol may be used. U.S. Pat. No.
5,702,752 is assigned to the assignee of this invention.
Other extraction processes, which may be used alone or in combination,
include differential solubility, distillation, solvent extraction,
adsorptive means, differential molecular filtration and precipitation.
The preferred composition is an improvement over known commercial
materials regarding the amount of phytochemicals per gram of substance and
the amounts of different phytochemicals present which affect physiologic
These natural substances have been consumed in food sources for long
periods of time and more closely relate to the substances consumed which
provide the basis for the epidemiological evidence for health benefits.
Additional benefits may be derived from improved physical properties
relative to phytochemicals chemically modified from their original food
The resulting composition is expected to comprise in a preferred form:
between 5% and 95% isoflavones, between 0% and 70% lignans, and between 2%
and 70% saponins and sapogenins. In a more preferred form, the composition
will be extracted from soy. In another preferred form, the composition
will contain a ratio of (saponins plus saponogenins) to isoflavones from
1:100 to 100:1, with the isoflavones consisting predominantly of naturally
occurring derivatives of genistein and/or its precursor biochanin A and
daidzein and/or its precursor formononetin, with a ratio of the genistein
derivatives to daidzein derivatives from 100:1 to 1:100. Preferably, the
isoflavones are predominantly glycosylated derivatives.
The composition's ratios may be readily varied by changing the plant
source or by combining several plant sources for extraction. Thus, as
further study shows which phytochemical combinations are more efficacious
for certain health effects, the particular composition will also vary.
It is known that isoflavones, lignans, and saponins can be used
advantageously to treat or prevent various cancers, including breast
cancer, prostate cancer, skin cancer, and colon cancer.
It is believed that the improved composition will provide increased
benefits in the form of chemoprevention. Recent experiments appear to
confirm this belief.
Claim 1 of 37 Claims
What is claimed is:
1. A method of treating a neurological condition selected from the group
consisting of migraine headaches, inflammations, dementia and Alzheimer's
Disease comprising administering to a person an amount therapeutically
effective in treating said neurological condition of a composition
comprising at least two fractions selected from the group consisting of
isoflavones, lignans, saponins and saponogenins, catechins, and phenolic
acids, said at least two phytochemical fractions being different from each
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