Title:  Compositions having comfrey and methods for reducing retinoid-induced skin irritation

United States Patent:  6,583,184

Issued:  June 24, 2003

Inventors:  Duggan; Michele C. (Middletown, NY)

Assignee:  Avon Products, Inc. (New York, NY)

Appl. No.:  722782

Filed:  November 27, 2000

Abstract

There is provided a topical composition for treating and/or preventing skin irritation induced by a retinoid. The composition has comfrey. There is also provided a method for treating and/or preventing skin irritation induced by a retinoid. An effective amount of comfrey is applied to the skin.

SUMMARY OF THE INVENTION

It is an object of the present invention to provide a topical composition having comfrey to treat, ameliorate and/or reduce or prevent skin irritation induced by a retinoid.

It is a further object of the present invention to provide a method for treating, that is ameliorating and/or reducing, skin irritation induced by a retinoid.

It is still a further object of the present, invention to provide a method for preventing irritation induced by a retinoid.

These and other objects of the present invention are achieved by a topical composition that has comfrey in an amount effective to prevent and/or treat skin irritation induced by a retinoid.

DETAILED DESCRIPTION OF THE INVENTION

The present invention relates to the surprising recognition that comfrey has a direct effect in mitigating skin irritation induced or caused by the topical use of a retinoid. It has been discovered that comfrey will treat, namely ameliorate and/or reduce, such irritation. It has also been discovered that comfrey will prevent such irritation. The efficacy of the retinoid in a topical composition will not be adversely affected by the addition of comfrey to the composition.

As stated above, retinoids are Vitamin A derivatives. Commonly used retinoids include, but are not limited to, retinal, retinol, retinoic acid, retinyl acetate, retinyl palmitate, retinyl propionate, isotretinoin, synthetic retinoid mimics, and tretinoin. The amount of retinoid in a topical composition varies depending on the condition to be treated or prevented, as well as on the composition and the retinoids themselves. However, for most conditions to be treater or prevented, the amount of retinoid in any composition is about 0.1 percentage by weight (wt %); but no greater than about 1.0 wt %, preferably no greater than about 0.5 wt %, since this amount is associated with some irritation and is always irritating to users with sensitive skin.

The comfrey of the present invention may be derived from any part of the comfrey plant (preferably, Symphytum officinale) These parts include the flowers, leaves, roots, seeds and stems. Preferably, the comfrey is extracted from the leaves and roots of the plant. The comfrey extract may be in the form of a liquid or powder. A suitable example of a comfrey extract is available from Cosmetochem under the tradename HERBASOL.TM.. It is an extract obtained from comfrey herbs in approximately 60:40 v:v water in propylene glycol solution. It is about 3.5% to 5.5% active.

Comfrey should be present in the topical composition of the invention in an amount, on an active basis, of at least about 0.005 wt % based on the total weight of the composition to treat retinoid-induced skin irritation. Preferably, comfrey is present in an amount at least about 0.005 wt %. to about 90 wt %, more preferably about 0.01 wt % to about 25 wt %, and most preferably about 0.01 wt. % to about 1.0 wt. % based on the total weight of the composition.

As a guideline, it is preferred that when the retinoid is retinol, the amount of comfrey to retinol ratio is from about 1:5 to about 10:1, more preferably from about 1:4 to about 5:1, or most preferably from about 1:3 to about 5:1.

It should be understood that the effect produced by a retinoid will vary by the type and amount of retinoid used in the topical composition. Accordingly, those skilled in the art will vary the amount to compensate for the various efficacies and concentrations associated with each retinoid, as well as the efficacy of the vehicle used. For example, drying vehicles, such as anhydrous gels, are generally considered to increase the potency/irritation of the retinoid as compared to emollient vehicles, such a oil-in-water creams.

The present invention functions against the irritating effect of a retinoid. As is known in the art, potencies of different retinoids vary. For example, retinoic acid is known to be more potent/irritating than retinol. In contrast, retinyl palmitate is known to be less potent than retinol. For this reason, retinyl palmitate is known to produce less irritation compared to retinol on a weight to weight basis. In fact, when retinyl palmitate is employed in commercial skin care products, there is virtually no irritation associated therewith. As a result, the maximum benefits of the present invention is achieved when the selected retinoid is not retinyl palmitate.

The present composition may take any suitable form such as a cream, an emulsion, a gel, a lotion, a patch, a stick, a towellete, a spray, a mask, an ointment or a solution. The composition preferably has a vehicle to provide bulk and physical form. Suitable vehicles include, but are not limited to, water, alcohols such as ethanol and polyvinyl alcohol, glycerin, propanol, propylene glycol, and mixtures thereof. The present composition may be in a form other than a tea.

The present composition may optionally have one or more of the following ingredients or adjuvants: anesthetics, anti-allergenics, antifungals, antiseptics, chelating agents, colorants, demulcents, pigment altering agents, emollients, emulsifiers, exfollients, fragrances, humectants, lubricants, moisturizers, preservatives, skin penetration enhancers, stabilizers, sunscreens, surfactants, thickeners, viscosity modifiers, vitamins, or mixtures thereof.

The inclusion of at least one sunscreen is particularly preferred since the retinoid may increase sensitivity of the skin to ultraviolet radiation. Preferably, the sunscreen provides both UVA and UVB protection, or is a combination of sunscreens that provide such protection. The preferred sunscreens are avobenzone, octyl salicylate, oxybenzone, titanium dioxide and cinnamic acid derivatives.

To form a topical composition according to the present invention, comfrey is incorporated into the composition by any suitable method known in the art. Preferably, the composition has both comfrey and a retinoid. The comfrey and retinoid may be admixed, preferably with a vehicle and any other adjuvants or ingredients, to form the topical composition.

When the composition includes comfrey, and no retinoid, the composition may be applied either before or after the retinoid is applied to the skin. Preferably, the topical composition having comfrey is applied either immediately before or immediately after the application of a composition containing the retinoid. More preferably, the topical composition of the present invention includes both comfrey and the retinoid for simultaneous application.

Claim 1 of 17 Claims

What is claimed is:

1. A method of treating, reducing, and/or ameliorating skin irritation induced by a retinoid, comprising applying to the skin a topical composition having an amount of comfrey effective to treat, reduce, and/or ameliorate the retinoid-induced skin irritation, wherein the topical composition is free of a cortisone.

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