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Title:  Anti-irritating rosacea treatment

United States Patent:  6,680,062

Issued:  January 20, 2004

Inventors:  Muizzuddin; Neelam (Bethpage, NY); Marenus; Kenneth D. (Dix Hills, NY); Maes; Daniel H. (Huntington, NY)

Assignee:  Color Access, Inc. (Melville, NY)

Appl. No.:  971561

Filed:  October 5, 2001

Abstract

The present invention relates to a cosmetic or pharmaceutical composition for topical application to the skin afflicted with rosacea and treated with a retinoid. The composition for treating rosacea comprises an anti-irritating component and several other components for treating rosacea. The other components form a mixture of a salicylic acid, a phytosphingosine, green tea, hinokitiol, gorgonian extract, and polysaccharide. The invention also provides a method for decreasing the irritation on the skin caused by the heightened sensitivity experienced by skin suffering from rosacea. The other components are effective in treating the rosacea condition, but particularly, in treating the telangiectasic symptom of rosacea.

SUMMARY OF THE INVENTION

The present invention relates to cosmetic and pharmaceutical compositions for topical application to skin treated with a retinoid for a condition of rosacea comprising, a phytosphingosine, an antioxidant component comprising at least green tea, an anti-bacterial component comprising at least hinokitiol and a salicylate, and an anti-irritating component comprising at least a polysaccharide and gorgonian extract. The compositions of the present invention are capable of treating the symptoms of rosacea, especially the symptoms related to telangiectasia, such as flushing, while also being substantially non-irritating. The treatment of rosacea is enhanced, and the potential irritation felt on the skin using the retinoid for rosacea treatment is minimized by a combination of the phytosphingosine, the antioxidant component comprising at least green tea, an anti-bacterial component comprising at least hinokitiol and the salicylate, and an anti-irritant component comprising at least a polysaccharide, a gorgonian extract component.

Other features of the present invention are the methods associated with the topical application of the substantially non-irritating rosacea treatment of the present invention. In particular, the present invention includes the method of decreasing the irritation of skin associated with rosacea treatment regimen of topically applied retinoid, the method of treating telangiectasia with phytosphingosine, and therefore, it also includes the method of reducing redness associated with the appearance of rosacea. The present invention is particularly beneficial when used in conjunction with rosacea treatments of topically applied retinoids.

DETAILED DESCRIPTION OF THE INVENTION

The rosacea treatment of the present invention is effective on skin treated with a retinoid for the rosacea condition. As previously mentioned, retinoids have proven useful in the treatment of acne rosacea. However, irritation can be experienced when using retinol to treat rosacea because of the heightened sensitivity of the facial skin suffering from rosacea. An unsaturated retinol fatty acid ester has been described in U.S. Pat. No. 5,885,595 whereby rosacea can be treated with less irritation. However, the present formulations succeed in reducing the irritation typically associated with rosacea treatment using different types of retinoids. Therefore, the rosacea sufferer can choose from a variety of retinol treatment regimens. The retinoid used to treat rosacea can be retinol (Vitamin A) and any of its derivatives, such as for example, retinyl palmitate, retinal, retinyl acetate, retinoic acid, and the like. The retinoid is used in an amount sufficient to effectively treat the symptoms of rosacea in combination with the other components of the present invention. The retinoid can be incorporated in the compositions of the present invention or be part of a separate treatment. However, preferably, the application of retinoids is part of a separate topical rosacea treatment regimen. The specific amounts of the retinoid can be, for example, about 0.001 to 5.00 percent, more preferably about 0.01 to 2.00 percent, concentration by weight of the total composition for rosacea treatment.

The compositions of the present invention include a cocktail of ingredients especially designed to alleviate the irritation experienced when treating rosacea, especially with a retinoid. Further, it has been surprisingly found that the inclusion of a phytosphingosine with the other active ingredients of the present invention, improves the condition of telangiectasia associated with rosacea. Although redness occurs with an inflammatory response or a deranged regulation of cell growth and differentiation of keratinocytes, the redness due to telangiectasia is vascular, and therefore, treatment for redness due to an inflammatory response will not necessarily treat redness due to vascular dilation, and most likely will not at all. Thus, the treatment of redness associated with rosacea, even when the skin is being treated for rosacea which can further irritate the skin, with the phytosphingosine and the other components of the present invention is unexpected. Some of the other active agents in the rosacea treatments of the present invention have been previously used in the treatment of rosacea. However, they have not been previously used with the phytosphingosine or collectively with one another as they are in the present invention to reduce irritation associated with a retinoid-containing rosacea treatment.

The phytosphingosine component is also known as an added active ingredient in cosmetic and pharmaceutical compositions, as explained in WO 00/01839 and in WO 99/29293, for their anti-inflammatory and antimicrobial activity, and as described in JP 2000109409, a phosphate of sphingosine for use in preventing acne. The contents of these references are incorporated herein. However, WO 00/01839 describes an enhanced method of producing sphingoid bases and derivatives such as phytosphingosines and, WO 99/29293 teaches a combination of a ceramide and a free sphingoid base which, when topically applied, allegedly benefit bacterial, fungal, yeast and viral infections, including rosacea. It has been taught in U.S. Pat. No. 5,792,794, also incorporated herein by reference, that coupling-products of retinoic acid or analogues with sphingoid bases such as phytosphingosines were stable and lacked irritating qualities similar to retinol derivatives retinyl-acetate and -palmitate. The compound is a sphingoid base linked through an amide to a retinoic acid. However, it has not been taught that the phytosphingoid by itself, or the other components of the present invention in simple admixture with a phytosphingoid (i.e., as separate components) can be substantially nonirritating especially when used in conjunction with a retinoid treatment for rosacea, nor has it been taught that a phytosphingoid by itself, or in combination with the other components, has any inherent effect on telangiectasia through anti-angiogenesis activity.

The effect of phytosphingosine in the present invention for treating telangiectasia is measured by the reduction of the flow of blood in facial skin. As shown in FIG. 1, the phytosphingosine acts in combination with the other components of the present invention as a vasoconstrictor. After four months of treatment, blood flow to the facial skin is reduced by about 25 percent. In addition, the presence of phytosphingosine also contributes to other known benefits such as treating acne comedones, serving as a building block for new ceramides, inducing de novo biosynthesis of ceramides, and acting as an important physiological regulator of growth and differentiation of epidermal cells as described in U.S. Pat. No. 5,792,794. The amount of the phytosphingosine used in the present invention for treating telangiectasia is from about 0.01 to about 10.0 percent by weight of the composition. Preferably, the amount of phytosphingosine is about 0.5 to 5.0 percent. The phytosphingosine of the present invention is available commercially from Gist-Brocades, Netherlands.

One of the other components of the present invention is the anti-bacterial component which comprises at least a salicylate and a hinokitiol. As used in the present specification, salicylates, known for treating skin microflora, can be, for example, salicylic acid, a common component of cosmetic and pharmaceutical compositions, and other salicylic acid esters. Preferably, the salicylate is a salicylic acid. However, currently available salicylic acid treatments are typically aggressive and too harsh for the skin plagued with rosacea as disclosed in U.S. Pat. No. 5,728,732, the contents of which are incorporated herein. Further, it is not known that salicylic acid can be used in combination with the other components of the present invention to treat rosacea with substantially less irritation than is normally experienced with rosacea treatment regimens. The salicylate is present in an amount of about 0.1 to 5.0 percent, preferably, 0.1 to 1.0 percent by weight of the composition.

Hinokitiol, 2-hydroxy-4-(1-methylethyl)-2,4,6-cycloheptatrien-1-one isopropyltropolone is a wood extract obtainable from for example, pine or cedar. This material is known to have potent antimicrobial effects, and, as such, has been previously used for a variety of purposes. As shown in U.S. Pat. No. 5,811,114, the contents of which are incorporated herein by reference, hinokitiol also possesses an anti-irritancy effect. The amount of hinokitiol useful in the present invention is about 0.01 to 0.5 percent, and preferably 0.1 to about 0.2 percent by weight of the composition.

The antioxidant component of the present invention prevents the harmful effects caused by reactive oxygen species or oxidants on the health of the skin and some antioxidants act as an anti-inflammatory agent. In the present invention, the antioxidant component preferably comprises at least green tea which contains volatile oil, vitamins, minerals, caffeine and the active ingredient polyphenol. The polyphenol is a catechin, epigallocatechin gallate (EGCG) and is also believed to have antibacterial properties. The polyphenol is also known as an antioxidant. The incorporation of an antioxidant in a composition for treating rosacea is disclosed in U.S. Pat. No. 5,972,993, and green tea and a sunscreen, including a salicylate, is disclosed in U.S. Pat. No. 5,306,486, the contents of which are incorporated herein. Other known antioxidants can be used such as, for example, but not limited to, vitamins such as vitamin C and vitamin E, BHT, extracts from various plants, such as for example, rosemary. The green tea is present in an amount of about 0.1 to 0.5 percent by weight of the composition.

The anti-irritant component of the present invention comprises at least a polysaccharide and gorgonian extract. The extracts of gorgonian are also known to have antimicrobial activity as reported by Jensen, P. R., et al., "Antimicrobial activity of extracts of Caribbean gorgonian corals", Marine Biology, vol. 125, pp. 411 to 419 (1996). Caribbean gorgonians (Octocorallia gorgonacea, Phylum cnidaria) are a diverse group of marine animals which are commonly known as sea whips and sea fans. Upon analysis of the Caribbean gorgonian, it has been found that they are or can be a biologically active source of pseudopterosin, steroids, prostaglandins, lactones, sesquiterpenoid derivatives, and diterpenoid metabolites, such as, for example, diterpenoid glycosides. As described in U.S. Pat. No. 5,624,911, ether derivatives of pseudopterosin, derived from marine sea whip, are effective anti-inflammatory and analgesic agents. Gorgonian extract is available commercially from Centerchem, Stamford, Conn. The gorgonian extract is present in an amount of about 0.01 to 0.5 percent, preferably 0.05 to 0.2 percent by weight of the composition.

Although any polysaccharide can be used in the compositions of the present invention, the polysaccharide of the present invention is preferably an extract of red algae, of the species, Porphyridium. The polysaccharide is commercially available from Earth Salts Company. As described in U.S. Pat. No. 5,089,481 and International Patent Application WO 97/00689, the red algae polysaccharide is chemically composed of mostly xylose, glucose, and galactose. Both of these references are incorporated herein by reference. In particular, the red algae polysaccharide contains, in addition to galactose, a dimethyl galactose. As the algae grow in a liquid medium, polysaccharide is released from the cell surface. Thus, polysaccharide can be collected from the excretions of algae in a growth medium or, alternatively, it can be obtained from the cell walls by extraction. It has been known that algal polysaccharides inhibit the activity of viruses such as human immunodeficiency virus reverse transcriptase enzyme and herpes simplex virus. However, the ability of these polysaccharides to reduce irritation associated with the rosacea condition has not previously been described. Specifically, it has not been known to incorporate the red microalgae polysaccharide of the present invention in combination with the other anti-irritants in the anti-irritant component to treat rosacea without substantial irritation. The polysaccharide is present in an amount of about 0.5 to 2.0 percent by weight of the composition.

While not so limited, in a preferred embodiment, the emulsion of the invention is an oil-in-water emulsion. The aqueous phase may be any cosmetically acceptable water based material, such as deionized water, or a floral water. The oil phase may be any cosmetically or pharmaceutically acceptable oil, such an oil being defined for the present purpose as any pharmaceutically or cosmetically acceptable material which is substantially insoluble in water. The oils may be volatile or non-volatile, or a mixture of both. For example, suitable volatile oils include, but are not limited to, both cyclic and linear silicones, such as cyclomethicone, octamethylcyclotetrasiloxane, and decamethylcyclopentasiloxane; or straight or branched chain hydrocarbons having from 8-20 carbon atoms, such as decane, dodecane, tridecane, tetradecane, and C8-20 isoparaffins.

Non-volatile oils include, but are not limited to, di- or triglycerides, vegetable oils, such as coconut oil, jojoba oil, corn oil, sunflower oil, palm oil, soybean oil; carboxylic acid esters such as isostearyl neopentanoate, cetyl octanoate, cetyl ricinoleate, octyl palmitate, dioctyl malate, coco-dicaprylate/caprate, decyl isostearate, myristyl myristate; animal oils such as lanolin and lanolin derivatives, tallow, mink oil or cholesterol; glyceryl esters, such as glyceryl stearate, glyceryl dioleate, glyceryl distearate, glyceryl linoleate, glyceryl myristate; non-volatile silicones, such as dimethicone, dimethiconol, dimethicone copolyol, phenyl trimethicone, methicone, simethicone; and nonvolatile hydrocarbons, such as isoparaffins, squalane, or petrolatum.

The emulsions may also comprise other optional components, depending on the intended end use. These include, but are not limited to, water soluble colorants (such as FD&C Blue #1); oil soluble colorants (such as D&C Green #6); water soluble sunscreens (such as Eusolex 232); oil soluble sunscreens (such as Octyl Methoxycinnamate); particulate sunscreens (such as Zinc Oxide); antioxidants (such as BHT); chelating agents (such as Disodium EDTA); emulsion stabilizers (such as carbomer); preservatives (such as Methyl Paraben); fragrances (such as pinene); flavoring agents (such as sorbitol); humectants (such as glycerine); waterproofing agents (such as PVP/Eicosene Copolymer); water soluble film-formers (such as Hydroxypropyl methylcellulose); oil-soluble film formers (such as Hydrogenated C-9 Resin); cationic polymers (such as Polyquatemium 10); anionic polymers (such as xanthan gum); vitamins (such as Tocopherol); and the like. However, any additional optional component must not interfere with the reduction in irritation and the anti-angiogenesis activity achieved by the components of the present invention.

The invention is further illustrated by the following non-limiting examples.

EXAMPLES

Example I

                Ingredient                   Percent
                Phase I
                Deionized Water                64.40
                Methyl Paraben                  0.10
                Sodium Hinokitiol               0.15
                Phenoxyethanol                  0.10
                Phase II
                Hyaluronic Acid                 0.10
                Methylcellulose                 0.50
                Phase III
                Deionized Water                12.15
                Salicylic Acid                  0.50
                Phase IV
                Phytosphingosine                0.20
                Dimethicone                     5.00
                Cyclomethicone                 15.00
                Green Tea                       0.40
                Gorgonian Extract               0.20
                Polysaccharide                  1.10
                Fragrance                       0.10

A composition according to the present invention is prepared as follows:

To prepare the composition, combine the Phase I ingredients. Add the Phase II ingredients to the Phase I ingredients when they are clear and uniform. Premix Phase II ingredients and combine with the Phases I and II ingredients. Add Phase IV ingredients to the combined Phases I, II and III.

Claim 1 of 10 Claims

What we claim is:

1. A topical cosmetic or pharmaceutical composition for skin treated with a retinoid for a condition of rosacea, comprising a combination of

a phytosphingosine;

an antioxidant component; comprising at least a green tea

an anti-bacterial component comprising at least hinokitiol and a salicylate; and

an anti-irritating component comprising at least a polysaccharide and gorgonian extract.



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