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Title:  Neuroceutical for improving memory and cognitive abilities

United States Patent:  6,733,797

Issued:  May 11, 2004

Inventors:  Summers; William K. (2400 Louisiana, NE., Suite 530, Albuquerque, NM 87110)

Appl. No.:  992132

Filed:  November 15, 2001

Abstract

The present invention relates to a neurochemical formulation comprising a supplement for improving function of neurons, improving memory and cognitive abilities, and reversing free radical damage caused by aging or neurodegenerative disease. The formulation comprises phosphoesters and antioxidants. Components may have antioxidant properties or enhance properties of other components. The synergistic combinations allow individual component dosages to be reduced, thereby minimizing potential toxicity.

SUMMARY OF THE INVENTION (DISCLOSURE OF THE INVENTION)

Surprisingly, and contrary to the teachings of the prior art, certain combinations of substances are found to give improved nervous system function with improved cognitive function and mental energy. The present invention is a supplement combination including at least one, and preferably at least two, phosphoesters and at least one antioxidant, preferably comprising at least one but not more than five antioxidant amino acids and at least one but not more than fifteen antioxidant vitamins and at least one antioxidant mineral.

The composition of the present invention exhibits synergistic antioxidant and restorative effects on the nervous system effective in treating neurodegenerative disorders where oxidative injury is believed to be contributory. These synergistic effects additionally allow use of lower doses of most of the individual components.

The present invention is a health supplement composition for mammals comprising at least one phosphoester and at least one synergistic antioxidant combination, wherein the synergistic antioxidant combination comprises at least one antioxidant and at least one other composition component that has a synergistic relationship with the antioxidant.

The composition of the present invention comprises at least one application method selected from the group consisting of oral, parenteral, rectal, and topical administration. Further, administration on mammals comprises prevention or treatment of illnesses selected from the group consisting of AIDS-associated dementia, Alzheimer's disease, benign senile forgetfulness, Down's syndrome-associated dementia, Lewy body dementia, multi-infarct dementia, multiple sclerosis, Parkinson's disease-associated dementia, tardive dyskinesia, Wernicke-Korsikoff syndrome, and alcoholism-associated dementia.

The phosphoester of the composition of the present invention is selected from the group consisting of phoshatidylcholine, phosphatidylserine, phosphatidylethanolamine and phosphatidylinositol. Preferably, two phosphoesters are used in the composition.

The antioxidant combination of the present invention comprises at least one member selected from the group of antioxidants consisting of herbal, amino acid, mineral, and vitamin antioxidants. The herbal antioxidant comprises at least one member selected from compounds derived from the group consisting of citrus fruits, citrus peels, curcuma, ginkgo biloba, ginseng, gotu kola, proanthocyanidins, quercetin, and Siberian ginseng. The amino acid antioxidant comprises at least one member selected from the group consisting of acetyl-L-camitine, L-glutamine, N-acetyl-L-cystine, L-lysine, L-methionine, and L-taurine. The antioxidant vitamin comprises at least one member selected from the group consisting of vitamin A, vitamin B1, vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B12, beta-carotene, vitamin C, vitamin E, L-glutathione, lipoic acid, lutein, lycopene, ubiquinone, and zeaxanthin. The antioxidant mineral comprises at least one member selected from the group consisting of boron, chromium, manganese, magnesium, selenium, and zinc.

The phosphoester of the composition may comprise a daily dosage of between approximately 0 mg and approximately 16,000 mg of phosphatidylcholine, between approximately 0 mg and approximately 300 mg of phosphatidylserine, between approximately 0 mg and approximately 500 mg of phosphatidylethanolamine, and between approximately 0 mg and approximately 10,000 mg of phosphatidylinositol. The phosphoester of the composition preferably comprises a daily dosage of between approximately 0 mg and approximately 1000 mg of phosphatidylcholine, between approximately 0 mg and approximately 100 mg of phosphatidylserine, between approximately 0 mg and approximately 200 mg of phosphatidylethanolamine, and between approximately 0 mg and approximately 1000 mg of phosphatidylinositol.

The herbal antioxidant of the composition comprises a daily dosage of between approximately 0 mg and approximately 7 mg of barberry, between approximately 0 mg and approximately 70 mg of bilberry proanthocyanidins, between approximately 0 mg and approximately 150 mg of lemon bioflavinoids, between approximately 0 mg and approximately 150 mg of lime bioflavinoids, between approximately 0 mg and approximately 150 mg of orange bioflavinoids, between approximately 0 mg and approximately 1000 mg of curcuma, between approximately 0 mg and approximately 2 mg of garlic bioflavinoids, between approximately 0 mg and approximately 180 mg of ginko biloba, between approximately 0 mg and approximately 2000 mg of ginseng, between approximately 0 mg and approximately 100 mg of gotu kola, between approximately 0 mg and approximately 1000 mg of grape seed proanthocyanidins, between approximately 0 mg and approximately 1000 mg of red apple quercetin, between approximately 0 mg and approximately 1000 mg of red onion quercetin, and between approximately 0 mg and approximately 400 mg of Siberian ginseng. The herbal antioxidant preferably comprises a daily dosage of between approximately 0 mg and approximately 35 mg of barberry, between approximately 0 mg and approximately 35 mg of bilberry proanthocyanidins, between approximately 0 mg and approximately 75 mg of lemon bioflavonoids, between approximately 0 mg and approximately 75 mg of lime bioflavonoids, between approximately 0 mg and approximately 75 mg orange bioflavonoids, between approximately 0 mg and approximately 500 mg of curcuma, between approximately 0 mg and approximately 1 mg of garlic bioflavonoid, between approximately 0 mg and approximately 250 mg of ginkgo biloba, between approximately 0 mg and approximately 1000 mg of ginseng, between approximately 0 mg and approximately 50 mg of gotu kola, between approximately 0 mg and approximately 500 mg of grape seed proanthocyanidins, between approximately 0 mg and approximately 500 mg of red apple quercetin, between approximately 0 mg and approximately 500 mg of red onion quercetin, and between approximately 0 mg and approximately 200 mg Siberian ginseng.

The antioxidant amino acid of the composition comprises a daily dosage of between approximately 0 mg and approximately 1500 mg of acetyl-L-camitine, between approximately 0 mg and approximately 1500 mg of L-glutamine, between approximately 0 mg and approximately 1500 mg of L-lysine, between approximately 0 mg and approximately 1500 mg of L-methionine, between approximately 0 mg and approximately 1500 mg of L-taurine, between approximately 0 mg and approximately 1500 mg of N-acetyl-L-cystine, and between approximately 0 mg and approximately 800 mg S-adenosylmethionine. The antioxidant amino acid preferably comprises a daily dosage of between approximately 0 mg and approximately 800 mg of acetyl-L-camitine, between approximately 0 mg and approximately 800 mg of L-glutamine, between approximately 0 mg and approximately 800 mg of L-lysine, between approximately 0 mg and approximately 800 mg of L-methionine, between approximately 0 mg and approximately 800 mg of L-taurine, between approximately 0 mg and approximately 800 mg of N-acetyl-L-cystine, and between approximately 0 mg and approximately 800 mg of S-adenosylmethionine.

The antioxidant vitamin of the composition comprises a daily dosage of between approximately 0 mg and approximately 50,000 IU of beta carotene, between approximately 0 mg and approximately 10,400 IU of vitamin A, between approximately 0 mg and approximately 1000 mg of vitamin B1, between approximately 0 mg and approximately 10 mg of vitamin B2, between approximately 0 mg and approximately 1000 mg of vitamin B3, between approximately 0 mg and approximately 500 mg of vitamin B5, between approximately 0 mg and approximately 500 mg of vitamin B6, between approximately 0 mg and approximately 500 mg of vitamin B6 (pyridoxal 5'-phosphate), between approximately 0 mg and approximately 1000 mg of vitamin B12, between approximately 0 mg and approximately 3000 mg of vitamin C, between approximately 0 mg and approximately 800 mg of vitamin E, between approximately 0 mg and approximately 1000 mcg of folic acid, between approximately 0 mg and approximately 2000 mg of L-glutathione, between approximately 0 mg and approximately 400 mg of lipoic acid between approximately 0 mg and approximately 30 mg of lutein, between approximately 0 mg and approximately 15,000 mcg of lycopene, between approximately 0 mg and approximately 600 mg of ubiquinone, and between approximately 0 mg and approximately 500 mg of zeaxanthin.

The antioxidant mineral of the composition comprises a daily dosage of between approximately 0 mg and approximately 100 mcg of boron, between approximately 0 mg and approximately 200 mcg of chromium, between approximately 0 mg and approximately 50 mg of manganese, between approximately 0 mg and approximately 1000 mg of magnesium, between approximately 0 mg and approximately 200 mcg of selenium, and between approximately 0 mg and approximately 100 mg of zinc.

The composition may additionally comprise at least one component selected from the group consisting of Bomelain, papain, and betaine. These may comprise a daily dosage of between approximately 0 mg and approximately 80 mg of Bohemian, between approximately 0 mg and approximately 50 mg of papain, and between approximately 0 mg and approximately 50 mg of beeline.

The resultant synergistic antioxidant compound may comprise at least one phosphoester and at least one herbal antioxidant, at least one phosphoester and at least one antioxidant mineral; at least one phosphoester and at least one antioxidant amino acid; at least one phosphoester and at least one antioxidant vitamin; at least one herbal antioxidant and at least one antioxidant mineral; at least one herbal antioxidant and at least one antioxidant amino acid; at least one antioxidant vitamin, at least one antioxidant mineral and at least one antioxidant amino acid; at least one antioxidant mineral and at least one antioxidant vitamin; at least one antioxidant amino acid and at least one antioxidant vitamin; at least one herbal antioxidant, at least one antioxidant mineral, and at least one antioxidant amino acid; at least one herbal antioxidant, at least one antioxidant mineral, and at least one antioxidant vitamin; and at least one antioxidant mineral, at least one antioxidant amino acid, and at least one antioxidant vitamin.

A primary object of this invention is to provide a composition for treatment of neurodegenerative disorders for administration to mammals that exhibits synergistic antioxidant and restorative effects on the nervous system.

A primary advantage of this invention is a lowered dosage requirement for components.

DESCRIPTION OF THE PREFERRED EMBODIMENTS (BEST MODES FOR CARRYING OUT THE INVENTION)

The present invention is a supplement combination including at least one, and preferably at least two, phosphoesters and at least one antioxidant, preferably comprising at least one but not more than five antioxidant amino acids and at least one but not more than fifteen antioxidant vitamins and at least one antioxidant mineral. These certain combinations of substances are found to give improved nervous system function with improved cognitive function and mental energy.

The composition of the present invention exhibits synergistic antioxidant and restorative effects on the nervous system effective in treating neurodegenerative disorders where oxidative injury is believed to be contributory. These synergistic effects allow use of lower doses of most of the individual components. The specific dosing limits of the present invention avoid toxic effects from elevated levels of components such as vitamin B2 and selenium. Use of easily absorbed vitamin forms such as riboflavin 5' phosphate (activated vitamin B2) or methylcobalamin (vitamin B12) in the present invention also allows consistent absorption and utilization by mammals.

The composition of the present invention comprises a phosphoester. The essential phosphoester preferably comprises phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine, and/or phosphatidylinositol. These compounds enhance cholinergic neurotransmission and general nerve cell membrane maintenance. The dosage of phosphatidylcholine of the present invention is preferably higher than dosages generally accepted in prior art compounds for lecithin. Combinations of phosphomonoester and/or phosphodiester compounds with enhancement compounds such as DMAE (dimethylaminoethanol), L-glutamine (a precursor of GABA, an antidepressant neurotransmitter), and succinate (Krebs cycle generation intracellular energy substrate), result in unanticipated cognitive improvement.

The composition of the present invention further comprises at least one antioxidant. The preferred antioxidants of the present invention comprise herbal, amino acid, mineral, and vitamin antioxidants. Useful, herbal antioxidants include, but are not limited to, beta carotene, various bioflavonoids (co-enzyme Q10, curcuma, ginkgo biloba (preferably an extract), ginseng (preferably American, Korean or Siberian), Gotu Kola, grape pip (proanthocyanidins), and quercetin). Useful amino acid antioxidants include, but are not limited to, L-arginine, L-glutathione, L-lysine, L-methionine, L-taurine, and L-camitine. Useful mineral antioxidants include, but are not limited to, boron, selenium (e.g., sodium selenite and selenium methionine), manganese (e.g., citrate), magnesium (preferably elemental) and zinc. Useful vitamin antioxidants include, but are not limited to, vitamins A, B, C, E and folic acid (pteroylgutamic acid). The preferred B vitamins are B1 (thiamine HCl), B2 (preferably riboflavin 5'-phosphate), B3 (niacinamide), B6 (preferably pyridoxine HCl and activated pyridoxal 5'-phosphate), and B12 (methylcobalamin). Other preferred vitamins are vitamin A (palminate), and vitamin E (d-alpha tocopheryl succinate). Other preferred vitamers include alpha lipoic acid, lutein, lycopene (a carotenoid), succinate, ubiquinone (co-enzyme Q10), and zeaxanthin (a yellow carotenoid). Other forms or equivalents of these stated compounds may be utilized in alternative embodiments.

Synergy and bioavailability are unique in this formulation. For example, citrus bioflavonoids are antioxidants which also synergistically increase absorption of synthetic vitamin C, helping to maintain sustained blood levels of vitamin C in the blood. Another example of a synergistic relationship is use of acetyl-L-carnitine, which works synergistically raising sustained levels of glutathione and co-enzyme Q10 Vitamin E actually diminishes the toxicity of riboflavin. (See, Free Radical Biology and Medicine 1999:24. pp. 798-808.) It should be noted that not all vitamins or other components are capable of synergistic relationships. The present invention utilizes viable synergistic relationships of at least two components of the invention, preferably utilizing at least one antioxidant, to avoid toxicity, increase activity, or maintain desired component or other chemical levels. Betaine, Bromelain, and papain are preferably added to help increase bowel absorption and thus bioavailability. Lutein and zeaxanthin are also preferably included, for their ability to specifically enhance the beneficial effects of beta carotene and vitamin A.

A correlate of synergy and bioavailability is avoidance of antagonistic interactions of components. For example, iron is not included in the formulation of the present invention because it forms free radicals responsible for oxidative stress damage. Therefore, use of iron in a supplement composition has a resultant reduction in the antioxidant properties of the composition.

The preferred formulation of the present invention is in Table 1.

                      PREFERRED FORMULATION
                                                DAILY DOSE
        COMPONENT                                 (2BID)
        Beta Carotene                           14,000 IU
        Betaine anhydrous                          250 mg
        (trimethylglycine)
        Bioflavonoids (lemon)                       75 mg
        Boron Citrate                               79 mcg
        Chromium*                                  200 mg
        Coenzyme Q10                                30 mg
        Bromelain*                                  20 mg
        DMAE (dimethyl amino ethanol)               75 mg
        Folic Acid                                 180 mcg
        Ginkgo biloba extract                       60 mg
        Ginseng, American                         22.5 mg
        (15% panax quinquefolis)
        Gotu kola*                                  80 mg
        Grape pip (proanthocyanidins)              210 mg
        L-Glutathione                              210 mg
        L-Lysine                                   150 mg
        L-Methionine                               111 mg
        L-Taurine                                   75 mg
        Lipoic acid                                 45 mg
        Lutein*                                      4 mg
        Manganese (citrate)                         27 mg
        Magnesium oxide (elemental value)        135.9 mg
        Papain                                      15 mg
        Phosphatidyl Choline                       675 mg
        Phosphatidyl Serine                       22.5 mg
        Selenium aminoate                         17.4 mcg
        Calcium citrate                            372 mg
        Succinate (Calcium base soy source)*         100 mg
        Vitamin A (palmitate)                    5,400 IU
        Vitamin B1 (thiamine HCl                  24.7 mg
        Vitamin B2 (riboflavin 5'-phosphate)           9 mg
        Vitamin B3 (niacinamide)                  23.1 mg
        Vitamin B5 (pantothenic calcium)            54 mg
        Vitamin B6 (pyridoxine HCL)               23.1 mg
        "Activated" Vitamin B6                     7.8 mg
        (Pyridoxal 5'-phosphate)
        Vitamin B12 (methylcobalamin)              720 mcg
        Vitamin C (buffered ascorbic acid)         663 g
        Vitamin E (d-alpha tocopheryl succinate)         331 IU
        Zinc (Citrate)                            49.2 mg
        INACTIVE INGREDIENTS:
        Ethyl cellulose                          178.2 mg
        Magnesium Stearate                          60 mg
        Croscarmellose sodium                      210 mg
        Cellulose                                  1.4 gm
        Talc                                       160 mg
        Silicon dioxide                            160 mg

The preferred dosage range for the present invention is set forth in Table 2.

                             TABLE 2
               PREFERRED DOSAGE RANGE OF COMPONENTS
        COMPONENT                            DAILY DOSE RANGE
        Acetyl-L-carnitine                     0-1,500 mg
        Barberry                                   0-7 mg
        Beta Carotene                         0-50,000 IU
        Betaine anhydrous                      0-1,000 mg
        (trimethylglycine)
        Bilberry proanthocyanidins                0-70 mg
        Bioflavonoids (garlic)                     0-2 mg
        Bioflavonoids (lemon)                    0-150 mg
        Bioflavonoids (lime)                     0-150 mg
        Bioflavonoids (orange)                   0-150 mg
        Boron Citrate                            0-100 mcg
        Chromium                                 0-225 mcg
        Coenzyme Q10                             0-120 mg
        Curcuma                                0-1,000 mg
        Betaine                                   0-50 mg
        Bromelain*                                0-80 mg
        DMAE (dimethyl amino ethanol)            0-500 mg
        Folic Acid                               0-250 mcg
        Ginkgo biloba extract                    0-250 mg
        Ginseng, American                      0-2,000 mg
        (15% panax quinquefolis)
        Ginseng, Siberian                        0-400 mg
        Gotu kola*                               0-100 mg
        Grape pip (proanthocyanidins)          0-1,000 mg
        L-Glutathione                          0-2,000 mg
        L-Lysine                               0-1,500 mg
        L-Methionine                           0-1,500 mg
        L-Taurine                              0-1,500 mg
        Lipoic acid                              0-400 mg
        Lutein*                                   0-30 mg
        Lycopene                              0-15,000 mcg
        Manganese (citrate)                       0-50 mg
        Magnesium oxide (elemental value)      0-1,000 mg
        N-acetyl-L-cystine                     0-1,500 mg
        Papain                                    0-50 mg
        Phosphatidyl Ethanolamine                0-500 mg
        Phosphatidyl Choline                      0-16 gm
        Phosphatidyl Inositol                 0-10,000 mg
        Phosphatidyl Serine                      0-300 mg
        Quercetin (red apple)                  0-1,000 mg
        Quercetin (red onion)                  0-1,000 mg
        Selenium aminoate                        0-200 mcg
        Calcium citrate                        0-2,400 mg
        S-adenosylmethionine                     0-800 mg
        Succinate (Calcium base soy source)*       0-300 mg
        Ubiquinone                               0-600 mg
        Vitamin A (palmitate)                 0-10,400 IU
        Vitamin B1 (thiamine HCl)              0-1,000 mg
        Vitamin B2 (riboflavin 5'-phosphate)        0-10 mg
        Vitamin B3 (niacinamide)               0-1,000 mg
        Vitamin B5 (pantothenic calcium)         0-500 mg
        Vitamin B6 (pyridoxine HCL)              0-500 mg
        "Activated" Vitamin B6                   0-500 mg
        (Pyridoxal 5'-phosphate)
        Vitamin B12 (methylcobalamin)          0-1,000 mcg
        Vitamin C (buffered ascorbic acid)     0-3,000 mg
        Vitamin E (d-alpha tocopheryl succinate)       0-800 IU
        Zeaxanthin                               0-500 mg
        Zinc (Citrate)                           0-100 mg

The most preferred dosage range for the present invention is set forth in Table 3.

                             TABLE 3
            MOST PREFERRED DOSAGE RANGE OF COMPONENTS
        COMPONENTS                           DAILY DOSE RANGE
        Acetyl-L-carnitine                    50-1000    mg
        Barberry                            1-        5  mg
        Beta Carotene                      13,000-15,000 IU
        Betaine anhydrous                   5-       50  mg
        (trimethylglycine)
        Bilberry proanthocyanidins         20-       50  mg
        Bioflavonoids (garlic)             0.1-        1   mg
        Bioflavonoids (lemon)               50-      100 mg
        Bioflavonoids (lime)                50-      100 mg
        Bioflavonoids (orange)              50-      100 mg
        Boron Citrate                       50-      100 mcg
        Chromium                           175-      225 mcg
        Coenzyme Q10                       25-       50  mg
        Curcuma                            400-      600 mg
        Betaine                            10-       45  mg
        Bromelain*                          5-       50  mg
        DMAE (dimethyl amino ethanol)      150-      250 mg
        Folic Acid                         150-      200 mcg
        Ginkgo biloba extract               25-      100 mg
        Ginseng, American                   5-      100  mg
        (15% panax quinquefolis)
        Ginseng, Siberian                  100-      400 mg
        Gotu kola*                          50-      100 mg
        Grape pip (proanthocyanidins)      175-      250 mg
        L-Glutathione                      175-      250 mg
        L-Lysine                           100-      200 mg
        L-Methionine                        75-      150 mg
        L-Taurine                           50-      100 mg
        Lipoic acid                         5-      100  mg
        Lutein*                             5-      100  mg
        Lycopene                            5,000-   15,000 mcg
        Manganese (citrate)                 1-       10  mg
        Magnesium oxide (elemental value)  100-     200  mg
        N-acetyl-L-cystine                  500-     1000 mg
        Papain                              5-       75  mg
        Phosphatidyl Ethanolamine          100-      350 mg
        Phosphatidyl Choline                500-     1000 mg
        Phosphatidyl Inositol               500-     1000 mg
        Phosphatidyl Serine                 5-      100  mg
        Quercetin (red apple)              100-      500 mg
        Quercetin (red onion)              100-      500 mg
        Selenium aminoate                   5-       75  mcg
        Calcium citrate                    200-      500 mg
        S-adenosylmethionine               300-      500 mg
        Succinate (Calcium base soy source)*     50-150    mg
        Ubiquinone                         300-      500 mg
        Vitamin A (palmitate)              2500-     7500 IU
        Vitamin B1 (thiamine HCl)           5-       75  mg
        Vitamin B2 (riboflavin 5'-phosphate)     5-  9     mg
        Vitamin B3 (niacinamide)             5-     1000 mg
        Vitamin B5 (pantothenic calcium)    5-      100  mg
        Vitamin B6 (pyridoxine calcium)     5-       75  mg
        "Activated" Vitamin B6              5-       75  mg
        (Pyridoxal 5'-phosphate)
        Vitamin B12 (methylcobalamin)       500-     1000 mcg
        Vitamin C (buffered ascorbic acid)  250-   750   mg
        Vitamin E (d-alpha tocopheryl succinate)   250- 750    IU
        Zeaxanthin                         250-      500 mg
        Zinc (Citrate)                      5-      100  mg

These dosages avoid toxic effect, and the combinations act synergistically to allow lower dosing as well as to avoid antagonist interaction. Finally, the components utilized focus on reducing or eliminating neurodegenerative effects, and further, improving cognitive and memory abilities.

Although the formulation of the invention requires at least one phosphoester and at least one oxidant, any of the other components shown in the Tables may be added to the formulation, separately or in combination, preferably in the dosage ranges shown in the Tables.

Of these components, the preferred key components useful in the formulation are as follows: phosphoesters, DMAE, L-glutamine, succinate, beta carotene, bioflavonoids, L-camitine, boron, manganese, magnesium, zinc, vitamins A, B, C, E, folic acid, and lutein.

The most preferred key components useful in the formulation are as follows: phophatidylcholine, DMAE, succinate, beta carotene, citrus bioflavinoids, and vitamin C.

Although the invention has been described in detail with particular reference to these preferred embodiments, other embodiments can achieve the same results. Variations and modifications of the present invention will be obvious to those skilled in the art and it is intended to cover in the appended claims all such modifications and equivalents. The entire disclosures of all references, applications, patents, and publications cited above are hereby incorporated by reference.

Claim 1 of 44 Claims

What is claimed is:

1. A health supplement composition for mammals for improving memory and cognitive abilities comprising:

at least one phosphoester in a daily amount of between approximately 5 mg and approximately 10,000 mg; and

at least one herbal antioxidant comprising a daily dosage of between approximately 1 mg and approximately 5 mg of barberry, between approximately 20 mg and approximately 50 mg of bilberry proanthocyanidins, between approximately 50 mg and approximately 100 mg of lemon bioflavonoids, between approximately 50 mg and approximately 100 mg of lime bioflavonoids, between approximately 50 mg and approximately 100 mg orange bioflavonoids, between approximately 400 mg and approximately 600 mg of curcuma, between approximately 0.1 mg and approximately 1 mg of garlic bioflavonoid, between approximately 25 mg and approximately 100 mg of ginkgo biloba, between approximately 5 mg and approximately 100 mg of ginseng, between approximately 50 mg and approximately 100 mg of gotu kola, between approximately 175 mg and approximately 250 mg of grape seed proanthocyanidins, between approximately 100 mg and approximately 500 mg of red apple quercetin, between approximately 100 mg and approximately 500 mg of red onion quercetin, and between approximately 100 mg and approximately 400 mg Siberian ginseng;

wherein said use on mammals comprises prevention or treatment of illnesses or conditions selected from the group consisting of a condition requiring memory improvement, cognitive improvement, AIDS-associated dementia, Alzheimer's disease, benign senile forgetfulness, Down's syndrome-associated dementia, Lewy body dementia, multi-infarct dementia, multiple sclerosis, Parkinson's disease-associated dementia, tardive dyskinesia, Wernicke-Korsikoff syndrome, and alcoholism-associated dementia.




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