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Title:  Gentle-acting skin disinfectants

United States Patent:  6,846,846

Issued:  January 25, 2005

Inventors:  Modak; Shanta (Riveredge, NJ); Gaonkar; Trupti A. (New York, NY); Sampath; Lester (Nyack, NY)

Assignee:  The Trustees of Columbia University in the City of New York (New York, NY)

Appl. No.:  047631

Filed:  October 23, 2001

Abstract

Antimicrobial compositions having synergistic combinations of octoxyglycerin and at least one other antimicrobial agent in formulations which are more effective than prior art compositions without causing increased irritation to the skin of the average user. In certain embodiments, skin irritation may be minimized by low concentrations of antimicrobials and/or the presence of soothing compounds such as zinc. Preferred embodiments include combinations of octoxyglycerin, a quaternary compound, and at least one other antimicrobial agent. Without being bound to any particular theory, it is hypothesized that the unexpected antimicrobial effectiveness of combinations of octoxyglycerin may result from an enhancement of the permeability of microbes to antimicrobials caused by octoxyglycerin.

Description of the Invention

1. INTRODUCTION

The present invention provides for skin-friendly antimicrobial compositions comprising synergistic combinations of octoxyglycerin and a low concentration of an antibiotic, particularly chlorhexidine. In particular embodiments, the compositions further comprise a quaternary ammonium compound that enhances killing of microbes.

2. BACKGROUND OF THE INVENTION

"Skin disinfectants" are routinely used in professional and non-professional contexts to rapidly kill microbes. A physician has a need to disinfect his or her skin both before and after examining a patient. Prior to the performance of an invasive medical procedure, the skin of the subject must be properly cleaned to avoid post-procedure infections. In non-professional contexts, a commuter, riding public transportation, may wish to disinfect her hands before handling food; a child, playing in a park, may need to clean his hands but not have the convenience of soap and water nearby. Each of these situations require, optimally, a skin disinfectant that is effective, easy to use, and non-irritating so as to permit repeated use.

A number of skin disinfectants have been developed that use alcohol as the primary antimicrobial agent. There are two general problems associated with alcohol-based disinfectants. First, the effective concentration of alcohol, generally regarded to be greater than about 60 percent weight (hereafter, all percentages should be considered weight/volume percentages, unless specified otherwise) of ethanol, or its equivalent, is irritating to the skin, causing dryness and consequent peeling and cracking. Because chapped skin tends to be more susceptible to microbial contamination, repeated use of alcohol disinfectants can exacerbate the very problem they are intended to solve. Second, whereas alcohol can be an effective disinfectant, once it evaporates its antimicrobial activity is lost.

Alcohol-based skin disinfectants which are known in the art, some of which address the two problems mentioned above, include the following.

U.S. Pat. No. 6,107,261 by Taylor et al., issued Aug. 22, 2000, and its continuations-in-part, U.S. Pat. No. 6,204,230 by Taylor et al., issued Mar. 20, 2001 and U.S. Pat. No. 6,136,771 by Taylor et al., issued Oct. 24, 2000, disclose antibacterial compositions which contain an antibacterial agent at a percent saturation of at least 50 percent. The compositions further comprise, as solubility promoters, a surfactant and a hydric solvent, which may be an alcohol.

U.S. Pat. No. 5,776,430 by Osborne et al., issued Jul. 7, 1998, discloses a topical antimicrobial cleaner containing about 0.65-0.85 percent chlorhexidine and about 50-60 percent denatured alcohol, which is scrubbed onto and then rinsed off the skin.

European Patent Application 0604 848 discloses a gel comprising an antimicrobial agent, 40-90 percent by weight of an alcohol, and a polymer and thickening agent.

U.S. Pat. No. 4,956,170 by Lee, issued Sep. 11, 1990 relates to a high alcohol content antimicrobial gel composition which comprises various emollients and a humectant to protect the skin from the drying effects of the alcohol. In alcohol formulations, higher levels of alcohol are needed to provide instant kill against sensitive as well as resistant strains of bacteria.

Certain formulations virtually omit alcohol as a primary antimicrobial agent, such as, for example, the skin sanitizing compositions disclosed in U.S. Pat. No. 6,187,327 by Stack, issued Feb. 13, 2001, which comprises triclosan (2,4,4'-trichloro-2'-hydroxydiphenyl ether; concentration 0.1-0.35 weight percent) in a topical lotion comprised of a surfactant phase and a wax phase, which purportedly provides antimicrobial protection for 3-4 hours after application. The composition prepared according to the claims of U.S. Pat. No. 6,187,327 further comprises chlorhexidine digluconate.

U.S. Pat. No. 5,965,610 by Modak et al., issued Oct. 12, 1999, teaches skin cleaning compositions comprising antimicrobial agents and zinc salts, where zinc salts have a soothing effect on the skin. The claimed subject matter includes formulations comprising a gel formed between zinc gluconate, chlorhexidine gluconate and a solvent, to which various thickening agents, emulsifying agents and/or emollients may be added.

U.S. Pat. No. 5,985,918 by Modak et al., issued Nov. 16, 1999, relates to "Zinc-Based Anti-Irritant Creams".

U.S. Pat. No. 5,705,532 by Modak et al., issued Jan. 6, 1998, relates to "Triple Antimicrobial Compositions" comprising less than or equal to two percent of a chlorhexidine compound, less than or equal to 0.1 percent of a quaternary ammonium compound, and less than or equal to two percent parachlorometaxylenol.

Octoxyglycerin, sold under the trade name Sensiva.RTM. SC50 (Schulke & Mayr), is a glycerol alkyl ether known to be gentle to the skin. Octoxyglycerine exhibits antimicrobial activity against a variety of Gram-positive bacteria associated with perspiration odor, such as Micrococcus luteus, Corynebacterium aquaticum, Corynebacterium flavescens, Corynebacterium callunae, and Corynebacterium nephredi, and is used in various skin deodorant preparations at concentrations between about 0.2 and 3 percent (Sensiva.RTM. product literature, Schulke & Mayr).

For example, U.S. Pat. No. 5,885,562 by Lowry et al., issued Mar. 23, 1999, relates to deodorant compositions comprising an antimicrobial agent, namely polyhexamethylene biguanide (at a concentration of between 0.01 and 0.5 percent), together with a polarity modifier such as Sensiva.RTM.SC50, at levels of typically 1-15 percent. Compositions disclosed in U.S. Pat. No. 5,885,562 may further comprise a short chain monohydric alcohol such as ethanol at a level of between 20 and 80 percent. Formulations useful as deodorants, however, would differ from those used as skin sanitizers in that skin sanitizers would optimally exhibit rapid broad spectrum activity against bacteria, fungi, and viruses, not merely gram positive odor causing bacteria.

U.S. Pat. No. 5,516,510 by Beilfuss et al., issued May 14, 1996, discloses deodorant compositions which comprise glycerin monoalkyl ethers such as octoxyglycerin (referred to therein as 2-ethyl hexyl glycerin ether, and as being the most preferred among these compounds). The deodorant compositions of U.S. Pat. No. 5,516,510 may be formulated in aqueous and/or alcoholic solutions and may further comprise additional antimicrobial compounds, including triclosan, chlorhexidine salts, alexidine salts, and phenoxyethanol, among others. Specific concentration ranges for triclosan and the biguanides are not provided.

3. SUMMARY OF THE INVENTION

The present invention relates to antimicrobial compositions comprising synergistic combinations of octoxyglycerin and at least one other antimicrobial agent in formulations which are more effective than prior art compositions without causing increased irritation to the skin of the average user. In certain embodiments, skin irritation may be minimized by low concentrations of antimicrobials and/or the presence of soothing compounds such as zinc. Preferred embodiments of the invention comprise combinations of octoxyglycerin, a quaternary ammonium compound, and at least one other antimicrobial agent. Without being bound to any particular theory, it is hypothesized that the unexpected antimicrobial effectiveness of combinations of octoxyglycerin may result from an enhancement of the permeability of microbes to antimicrobials caused by octoxyglycerin.

4. DETAILED DESCRIPTION OF THE INVENTION

The present invention relates to combinations of octoxyglycerin with at least one, and preferably at least two, antimicrobial agents. In preferred embodiments of the invention such compositions comprise octoxyglycerin and a quaternary ammonium compound.

Octoxyglyerin, as used herein, is also known as glycerol 1-(2-ethylhexyl) ether and is sold under the trade name Sensiva.RTM. SC 50 ("Sensiva.RTM.") by Schulke & Mayr (Rockaway, N.J.).

Antimicrobial agents which may be used in addition to octoxyglycerin according to the invention include biguanides and phenols. Biguanides may be used in concentrations between about 0.05 and 4 percent and preferably between about 0.05 and 2 percent. Examples of suitable biguanides include polyhexamethylene biguanide (PHMB) at concentrations between about 0.3 and 1 percent, alexidine at concentrations between about 0.5 and 2 percent, and chlorhexidine compounds at concentrations between about 0.5 and 4 percent and preferably between about 0.05 and 1 percent. A chlorhexidine compound, as that term is used herein, includes chlorhexidine free base as well as chlorhexidine salts, including, but not limited to, chlorhexidine diacetate (also known as "chlorhexidine acetate"), chlorhexidine digluconate (also known as "chlorhexidine gluconate"), chlorhexidine palmitate, chlorhexidine diphosphanilate, chlorhexidine dihydrochloride, chlorhexidine dichloride, chlorhexidine dihydroiodide, chlorhexidine diperchlorate, chlorhexidine dinitrate, chlorhexidine sulfate, chlorhexidine sulfite, chlorhexidine thiosulfate, chlorhexidine di-acid phosphate, chlorhexidine difluorophosphate, chlorhexidine diformate, chlorhexidine dipropionate, chlorhexidine di-iodobutyrate, chlorhexidine di-n-valerate, chlorhexidine dicaproate, chlorhexidine malonate, chlorhexidine succinate, chlorhexidine malate, chlorhexidine tartrate, chlorhexidine dimonoglycolate, chlorhexidine monodiglycolate, chlorhexidine dilactate, chlorhexidine di-alpha-hydroxyisobutyrate, chlorhexidine diglucoheptonate, chlorhexidine di-isothionate, chlorhexidine dibenzoate, chlorhexidine dicinnamate, chlorhexidine dimandelate, chlorhexidine di-isophthalate, chlorhexidine di-2-hydroxynapthoate, and chlorhexidine embonate. Most preferably, the chlorhexidine compound is chlorhexidine digluconate a concentration between 0.05 and 4 percent.

Phenols (phenol derivatives) which may be used according to the invention include, but are not limited to, 2-hydroxyphenol compounds such as triclosan (2,4,4'-trichloro-2'-hydroxydiphenyl ether, also available as IRGASAN DP300 from Ciba Specialty Chemicals Corp, Greensboro, N.C.) and 2,2'-dihydroxy-5,5'-dibromo-diphenyl ether; p-nitrophenol, picric acid, xylenol, phenoxyethanol, chlorinated phenols such as parachlorometaxylenol, p-chloro-o-benzylphenol and -dichlorophenol, cresols such as p-chloro-m-cresol, pyrocatechol, resorcinol, 4-n-hexylresorcinol, pryogallol, phloroglucin, carvacrol, thymol, p-chlorothymol, o-phenylphenol, o-benzylphenol, phenol, 4-ethylphenol, 4-phenolsulfonic acids, hexachlorophene, tetrachlorophene, dichlorophene, 2,3-dihydroxy-5,5'-dichlorophenyl sulfide, 2,2'-dihydroxy-3,3',5,5'-tetrachlorodiphenyl sulfide, 2,2'-dihydroxy-3,3',5,5',6,6'-hexachlorodiphenyl sulfide and 3,3'-dibromo-5,5'-dichloro-2,2'-dihydroxydiphenylamine. Preferred is triclosan at a concentration of between about 0.1 and 2 percent and most preferably between about 0.3 and 1 percent. Other phenols may be comprised at concentrations of between about 0.3 and 2 percent, but preferably at concentrations equivalent in potency against S. aureus as between 0.3 and 1 percent triclosan.

Additional antimicrobial agents which may be incorporated into compositions of the invention include antifungal agents such as miconazole (preferably at a concentration of 1-2 percent), polymixin (preferably at a concentration of 0.3-1 percent), neomycin (preferably at a concentration of 0.1-0.5 percent), iodine compounds such as povidone iodine (preferably at a concentration of 1-10 percent), minocycline (preferably at a concentration of 0.3-1.0 percent), and metal salts such as silver sulfadiazine (preferably at a concentration of 1-2 percent).

Preferred non-limiting embodiments of the invention comprise octoxyglycerin together with a quaternary ammonium compound, such as, but not limited to, benzalkonium chloride ("BZK", which is particularly preferred), benzethonium chloride, other benzalkonium or benzethonium halides, including, but not limited to, benzalkonium or benzethonium bromide or fluoride, cetyl pyridinium chloride, dequalinium chloride, N-myristyl-N-methyl-morpholinium methyl sulfate, poly[N-[3-(dimethylammonio)propyl]-N'-[3-(ethyleneoxyethelene dimethylammoinio)propyl]urea dichloride], alpha-4-[1-tris(2-hydroxyethyl)ammonium chloride-2-butenyl]-omega-tris(2-hydroxyethyl)ammonium chloride, poly[oxyethylene (dimethyliminio)ethylene (dimethyliminio)-ethylene dichloride]. The concentrations of quaternary ammonium compound may be between about 0.01 and 0.3 percent; preferably the quaternary ammonium compound is benzalkonium chloride at a concentration between 0.05 and 0.2 percent, more preferably between 0.1 and 0.15 percent.

In certain non-limiting embodiments, compositions of the invention may further comprise one or more alcohol. Alcohols which may be used according to the invention include aliphatic alcohols, including, but not limited, most preferred ethanol or isopropyl alcohol, but also n-propyl alcohol, and mixtures thereof, at concentrations between about 20 and 85 percent and preferably 40 to 70 percent. Suitable alcohols also include fatty alcohols, such as cetyl alcohol, myristyl alcohol, stearyl alcohol, octyl alcohol, decyl alcohol, lauryl alcohol, and combinations thereof, at concentrations between about 0.5 and 5 percent. The present invention further provides for compositions comprising, as at least one alcoholic component, hexanol at a concentration of between three and ten percent and preferably about 5 percent.

The formulations of the invention may further comprise one or more of the following:

A zinc-containing compound such as a zinc salt, including but not limited to zinc gluconate, zinc oxide, zinc stearate, zinc salicylate, zinc carbonate, zinc oleate, zinc acetate, zinc peroxide, zinc phosphate, and zinc undecylenate. Zinc compounds are known to have anti-irritant activity (see, for example, U.S. Pat. No. 5,965,610 by Modak et al. and U.S. Pat. No. 5,985,918 by Modak et al., incorporated by reference herein). Preferred zinc compounds for use according to the invention are, for a disinfecting alcohol gel, zinc gluconate and zinc oxide, at concentrations between 0.1 and 1 percent, and preferably 0.8 percent zinc gluconate and 0.2 percent zinc oxide; for an antiseptic aqueous formulation, zinc gluconate and zinc stearate, at concentrations between 0.2 and 7 percent, and preferably 2.4 percent zinc gluconate and 3.8 percent zinc stearate.

An emollient, which may be, for example, an organic, a hydrocarbon-based or a fatty-ester based emollient. Suitable hydrocarbon-based emollients include petrolatum and mineral oils. Suitable fatty ester based emollients include methyl, isopropyl and butyl esters of fatty acids such as isopropyl palmitate, isopropyl myristate, isopropyl isostearate, isostearyl isostearate, diisopropyl sebacate, and propylene dipelargonate, 2-ethylhexyl isononoate, 2-ethylhexyl stearate, C12 -C16 fatty alcohol lactates such as cetyl lactate and lauryl lactate, isopropyl lanolate, 2-ethylhexyl salicylate, cetyl myristate, oleyl myristate, oleyl stearate, oleyl oleate, hexyl laurate, and isohexyl laurate. Additional useful emollients include lanolin, olive oil, cocoa butter, and shea butter.

A humectant, such as, for example, glycerine, 1-2-propylene glycol, dipropylene glycol, polyethylene glycol, 1,3-butylene glycol, or 1,2,6-hexanetriol.

A thickening and/or gelling agent, such as, for example, an addition polymer of acrylic acid, a resin such as Carbopol.RTM. ETD.TM. 2020, guar gum, acacia, acrylates/steareth-20 methacrylate copolymer, agar, algin, alginic acid, ammonium acrylate co-polymers, ammonium alginate, ammonium chloride, ammonium sulfate, amylopectin, attapulgite, bentonite, C9-15 alcohols, calcium acetate, calcium alginate, calcium carrageenan, calcium chloride, caprylic alcohol, carbomer 910, carbomer 934, carbomer 934P, carbomer 940, carbomer 941, carboxymethyl hydroxyethyl cellulose, carboxymethyl hydroxypropyl guar, carrageenan, cellulose, cellulose gum, cetearyl alcohol, cetyl alcohol, corn starch, damar, dextrin, dibenzlidine sorbitol, ethylene dihydrogenated tallowamide, ethylene diolamide, ethylene distearamide, gelatin, guar gum, guar hydroxypropyltrimonium chloride, hectorite, hyaluronic acid, hydrated silica, hydroxybutyl methylcellulose, hydroxyethylcellulose, hydroxyethyl ethylcellulose, hydroxyethyl stearamide-MIPA, hydroxypropylcellulose, hydroxypropyl guar, hydroxypropyl methylcellulose, isocetyl alcohol, isostearyl alcohol, karaya gum, kelp, lauryl alcohol, locust bean gum, magnesium aluminum silicate, magensium silicate, magnesium trisilicate, methoxy PEG-22/dodecyl glycol copolymer, methylcellulose, microcrystalline cellulose, montmorillonite, myristyl alcohol, oat flour, oleyl alcohol, palm kernel alcohol, pectin, PEG-2M, PEG-5M, polyacrylic acid, polyvinyl alcohol, potassium alginate, potassium aluminum polyacrylate, potassium carrageenan, potassium chloride, potassium sulfate, potato starch, propylene glycol alginate, sodium acrylate/vinyl alcohol copolymer, sodium carboxymethyl dextran, sodium carrageenan, sodium cellulose sulfate, sodium chloride, sodium polymethacylate, sodium silicoaluminate, sodium sulfate, stearalkonium bentotnite, stearalkonium hectorite, stearyl alcohol, tallow alcohol, TEA-hydrochloride, tragacanth gum, tridecyl alcohol, tromethamine magnesium aluminum silicate, wheat flour, wheat starch, xanthan gum, abietyl alcohol, acrylinoleic acid, aluminum behenate, aluminum caprylate, aluminum dilinoleate, aluminum salts, such as distearate, and aluminum isostearates, beeswax, behenamide, behenyl alcohol, butadiene/acrylonitrile copolymer, C29-70 acid, calcium behenate, calcium stearate, candelilla wax, carnauba, ceresin, cholesterol, cholesterol hydroxystearate, coconut alcohol, copal, diglyceryl stearate malate, dihydroabietyl alcohol, dimethyl lauramine oleate, dodecanoic acid/cetearyl alcohol/glycol copolymer, erucamide, ethylcellulose, glyceryl triacetyl hydroxystearate, glyceryl tri-acetyl ricinolate, glycol dibehenate, glycol di-octanoate, glycol distearate, hexanediol distearate, hydrogenated C6-14 olefin polymers, hydrogenated castor oil, hydrogenated cottonseed oil, hydrogenated lard, hydrogenated menhaden oil, hydrogenated palm kernel glycerides, hydrogenated palm kernel oil, hydrogenated palm oil, hydrogenated polyisobutene, hydrogenated soybean oil, hydrogenated tallow amide, hydrogenated tallow glyceride, hydrogenated vegetable glyceride, hydrogenated vegetable oil, Japan wax, jojoba wax, lanolin alcohol, shea butter, lauramide, methyl dehydroabietate, methyl hydrogenated rosinate, methyl rosinate, methylstyrene/vinyltoluene copolymer, microcrystalline wax, montan acid wax, montan wax, myristyleicosanol, myristyloctadecanol, octadecene/maleic anhyrdine copolymer, octyldodecyl stearoyl stearate, oleamide, oleostearine, ouricury wax, oxidized polyethylene, ozokerite, paraffin, pentaerythrityl hydrogenated rosinate, pentaerythrityl tetraoctanoate, pentaerythrityl rosinate, pentaerythrityl tetraabietate, pentaerythrityl tetrabehenate, pentaerythrityl tetraoleate, pentaerythrityl tetrastearate, phthalic anhydride/glycerine/glycidyl decanoate copolymer, phthalic/trimellitic/glycols copolymer, polybutene, polybutylene terephthalate, polydipentene, polyethylene, polyisobutene, polyisoprene, polyvinyl butyral, polyvinyl laurate, propylene glycol dicaprylate, propylene glycol dicocoate, propylene glycol diisononanoate, propylene glycol dilaurate, propylene glycol dipelargonate, propylene glycol distearate, propylene glycol diundecanoate, PVP/eiconsene copolymer, PVP/hexadecene copolymer, rice bran wax, stearlkonium bentonite, stearalkonium hectorite, stearamide, stearamide DEA-distearate, stearamide DIBA-stearate, stearamide MEA-stearate, stearone, stearyl alcohol, stearyl erucamide, stearyl stearate, stearyl stearoyl stearate, synthetic beeswax, synthetic wax, trihydroxystearin, triisononanoin, triisostearin, tri-isostearyl trilinoleate, trilaurin, trilinoleic acid, trilinolein, trimyristin, triolein, tripalmitin, tristearin, zinc laurate, zinc myristate, zinc neodecanoate, zinc rosinate, and mixtures thereof.

A neutralizing agent, which may be included, for example, to neutralize carboxyl groups present in one or more other component, such as carboxyl groups in a thickening agent. Suitable neutralizing agents include diisopropylamine and triethanolamine.

A surfactant, which may be an anionic surfactant, a cationic surfactant, an ampholytic surfactant, or a nonionic surfactant, such as, for example, nonionic surfactants such as polyethoxylates, fatty alcohols (e.g., ceteth-20 (a cetyl ether of polyethylene oxide having an average of about 20 ethylene oxide units) and other "BRIJ".RTM. nonionic surfactants available from ICI Americas, Inc. (Wilmington, Del.)), cocamidopropyl betaine, alkyl phenols, fatty acid esters of sorbitol, sorbitan, or polyoxyethylene sorbitan. Suitable anionic surfactants include ammonium lauryl sulfate and lauryl ether sulfosuccinate. A preferred surfactant is lauroyl ethylenediamine triacetic acid sodium salt at a concentration between about 0.5-2.0%. Suitable concentrations of surfactant are between about 0.05 and 2 percent.

Water used in the formulations is preferably deionized water having a neutral pH.

Additional additives, including but not limited to a silicone fluid (such as dimethicone or cyclomethicone), dyes, fragrances, etc. Examples of additional additives include but are not limited to: pH adjusters, including basic pH adjusters such as ammonia, mono-, di- and tri- alkyl amines, mono-, di- and tri-alkanolamines, alkali metal and alkaline earth metal hydroxides (e.g., ammonia, sodium hydroxide, potassium hydroxide, lithium hydroxide, monoethanolamine, triethylamine, isopropylamine, diethanolamine and triethanolamine); acid pH adjusters such as mineral acids and polycarboxylic acids (e.g., hydrochloric acid, nitric acid, phosphoric acid, sulfuric acid, citric acid, glycolic acid, and lactic acid); vitamins such as vitamin A, vitamin E and vitamin C; polyamino acids and salts, such as ethylenediamine tetraacidic acid (EDTA), preservatives such as DMDM hydantoin, and sunscreens such as aminobenzoic acid, arobenzone, cinoxate, diioxybenzone, homosalate, menthyl anthranilate, octocrylene, octyl methoxycinnamate, octyl salicylate, oxybenzoate, padimate O, phenylbenzimidazole, sulfonic acid, sulisobenzone, titanium dioxide, trolamine salicylate and zinc oxide.

Specific, non-limiting embodiments of the invention include the following compositions, which may further comprise additional ingredients which do not substantially effect the antimicrobial properties of the composition. For the following formulations, the water indicated was added last to the other ingredients to brind the total volume to 100 percent.

1. An antiseptic alcohol gel comprising:

    zinc gluconate                     0.8 percent
    zinc oxide                         0.2 percent
    ethyl alcohol                     65.0 percent (volume/volume)
    hydroxy methyl propyl              0.3 percent
    cellulose (K100M)
    Ucare JR 400 (polyquaternium-10)  0.15 percent
    (Amerchol Corp.)
    Incroquat Behenyl TMS              1.0 percent
    (Croda, Inc.)
    Polawax A-31                       1.0 percent
    (Croda, Inc.)
    stearyl alcohol - Crodacol(S70)    1.0 percent
    (Croda, Inc.)
    Cremerol HMG                       1.0 percent
    (Amerchol Corp.)
    dimethicone                        0.5 percent (volume/volume)
    Germall plus                      0.25 percent
    (ISP Sutton Laboratories)
    propylene glycol                   1.5 percent (volume/volume)
    glycerine                          1.0 percent (volume/volume)
    water                            23.13 percent (volume/volume)
    chlorhexidine digluconate         0.05 percent
    phenoxyethanol                     1.0 percent
    BZK                               0.12 percent
    Sensiva SC50                         2 percent (volume/volume)


where the gel may be applied to and rubbed over the skin to achieve its antimicrobial effect.

2. An antiseptic alcohol gel comprising:

    water                            31.32 percent (volume/volume)
    Ucare                             0.08 percent
    (Amerchol Corp.)
    hydroxypropylmethylcellulose (K-100)  0.15 percent
    (Dow Corning)
    Polyox WSR 301 (polyethyleneoxide)  0.03 percent
    (Dow Corning)
    Incroquat                          0.4 percent
    (Croda, Inc.)
    Polawax A-31                       0.4 percent
    (Croda, Inc.)
    polyethylene glycol               0.25 percent
    ethanol                           63.5 percent (volume/volume)
    Glucam E-20                        0.4 percent
    (Amerchol Corp.)
    Silicone 225                       0.1 percent (volume/volume)
    (Dow Corning)
    Sensiva SC50                       2.0 percent (volume/volume)
    phenoxyethanol                     1.0 percent
    chlorhexidine digluconate         0.05 percent
    BZK                               0.12 percent
    Germall Plus                       0.2 percent
    (Sutton Laboratories)

3. An antiseptic aqueous formulation comprising:

    zinc gluconate                     2.4 percent
    zinc stearate                      3.8 percent
    hydroxy methyl propyl              0.5 percent
    cellulose (K100M)
    Kytamer PC (Chitisan)             0.15 percent
    (Amerchol Corp.)
    Ucare JR 400                       0.1 percent
    (Amerchol Corp.)
    Incroquat behenyl TMS              1.0 percent
    (Croda, Inc.)
    Crodamol NM                        1.6 percent
    (Croda, Inc.)
    Acetulan                           2.0 percent
    (Amerchol Corp.)
    Cremerol HMG                       1.0 percent
    (Amerchol Corp.)
    stearyl alcohol                    2.0 percent
    allantoin                         0.25 percent
    Germall Plus                       0.3 percent
    (ISP Sutton Laboratories)
    dimethicone                        1.0 percent (volume/volume)
    water                            81.48 percent (volume/volume)
    PHMB                               0.3 percent
    phenoxyethanol                     1.0 percent
    BZK                               0.12 percent
    Sensiva SC50                         2 percent (volume/volume)


4. An antimicrobial scrub gel comprising:

    water                             30.5 percent
    Ucare                              0.1 percent
    (Amerchol Corp.)
    hydroxy propyl methyl cellulose (K100)   0.2 percent
    (Dow Corning)
    Polyox WSR 301 (polyethyleneoxide)   0.1 percent
    (Dow Corning)
    Incroquat                          0.4 percent
    (Croda, Inc.)
    Polawax A-31                       0.4 percent
    (Croda, Inc.)
    propylene glycol                   1.0 percent
    ethanol                           63.5 percent (volume/volume)
    Glucam E-20                        0.4 percent
    (Amerchol Corp.)
    Masil SF 19 CG surfactant          1.0 percent
    phenoxyethanol                     1.0 percent
    Sensiva SC50                       1.0 percent (volume/volume)
    chlorhexidine digluconate         0.05 percent
    BZK                               0.12 percent
    Germall Plus                       0.2 percent
    (Sutton Laboratories)

5. An antimicrobial scrub gel, for example for pre-operative skin disinfection, comprising:

    ethanol                             35 percent (volume/volume)
    isopropanol                         35 percent (volume/volume)
    zinc gluconate                     0.5 percent
    zinc oxide                         0.2 percent
    hydroxy methyl propyl              0.3 percent
    cellulose (K100M)
    Germall Plus                      0.25 percent
    (ISP Sutton Laboratories)
    hexanol                            5.0 percent (volume/volume)
    PXE                                1.0 percent
    Sensiva                            1.5 percent (volume/volume)
    chlorhexidine digluconate         0.05 percent
    with water added to 100 percent (approximately
    21.2 milliliters/100 ml solution).

6. Another antimicrobial scrub gel, for example for pre-operative skin disinfection, comprising:

    water                            23.28 percent (volume/volume)
    Polyox WSR 205                     0.2 percent
    U-care JR 400                      0.2 percent
    ethanol (95%)                       65 percent (volume/volume)
    propylene glycol                     3 percent
    Sensiva SC50                         2 percent (volume/volume)
    BZK                               0.12 percent
    phenoxyethanol                     1.0 percent
    povidone iodine                    5.0 percent
    Germall Plus                       0.2 percent


7. An antimicrobial soap comprising:

    water                             51.2 percent (volume/volume)
    Ucare                              0.1 percent
    (Amerchol Corp.)
    hydroxy propyl methyl              0.2 percent
    cellulose (K-100)
    (Dow Corning)
    Polyox WSR 301 (polyethyleneoxide)  0.03 percent
    ethanol                             40 percent (volume/volume)
    Pluronic F-87                      2.0 percent
    (BASF)
    Masil SF 19 CG surfactant          1.0 percent
    Cocamidopropyl betaine             2.0 percent
    (Witco Corp.)
    propylene glycol                   1.0 percent
    phenoxyethanol                     1.0 percent
    chlorhexidine digluconate         0.05 percent
    BZK                               0.12 percent
    Sensiva SC50                       0.5 percent (volume/volume)
    Germall Plus                       0.2 percent
    (Sutton Laboratories)


8. An antifungal cream comprising miconazole (1-2 percent), chlorhexidine digluconate (0.05-0.2 percent), and Sensiva SC50(1-3 percent) in a hydrophillic cream base.

9. A topical antiseptic ointment for wound care comprising polymixin (0.3-1%), neomycin (0.1-0.5 percent), chlorhexidine digluconate (0.05-0.2 percent), and Sensiva SC50(1-3 percent) in a hydrophillic base.

10. A topical antiseptic ointment for burn wound care comprising silver sulfadiazine (1-2 percent), chlorhexidine digluconate (0.05-0.2 percent) and Sensiva SC50 (1-3 percent) in a hydrophillic base.

Claim 1 of 40 Claims

We claim:

1. An antimicrobial composition comprising synergistic effective amounts of octoxyglycerin, a quaternary ammonium compound, and an antimicrobial agent selected from the group consisting of biguanide compound, triclosan, phenoxyethanol, an iodine compound and parachlorometaxylenol.


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