Patent 6,869,942

Inhalable pharmaceutical compositions are provided, for use in the treatment of respiratory disorders such as asthma, rhinitis and chronic obstructive pulmonary disease (COPD). These compositions have high storage stability, and include formoterol and a corticosteroid.

Description of the Invention

FIELD OF THE INVENTION

The present invention relates to a stable powder formulation comprising formoterol or enantiomers of formoterol, a glucocorticosteroid and a carrier or diluent for use in the treatment of inflammatory conditions/disorders, especially respiratory diseases such as asthma, COPD and rhinitis.

BACKGROUND OF THE INVENTION

Stability is one of the most important factors which determines whether a compound or a mixture of compounds can be developed into a therapeutically useful pharmaceutical product. When mixing different ingredients in a pharmaceutical formulation there exists the possibility of interactions taking place between the components. In addition, each component may have different degradation characteristics.

Formoterol is a highly potent and selective .beta.2-agonist with a long duration of action when inhaled. Compared to other .beta.-adrenergic compounds it has a unique chemical structure with a formamido group substituted on the benzene ring. It has two asymmetric carbon atoms in the molecule making four stereoisomers possible. Most studies, clinical and preclinical, appear to have been performed with the fumarate (as dihydrate) of the enantiomeric mixture designed R;R+S;S. The R;R enantiomer is the most potent of the four enantiomers.

The stability profile of the drug formoterol (mainly as fumarate dihydrate) has been evaluated by investigating the influence of variables such as storage time, temperature, relative humidity, light and pH on the content of formoterol and determining the amount of chromatographic impurities. Formoterol (as fumarate dihydrate) has been demonstrated to be stable under long-term storage even at high temperatures and high relative humidities.

However, the chemical structure of formoterol makes the molecule prone to chemical degradation when in contact with e.g. a reactive species like an aldehyde or under stress conditions e.g. a milling process.

Potent drugs for administration by inhalation are generally formulated in association with carriers/diluents such as lactose to facilitate accurate dosing from an inhaler. These formulations have generally consisted of coarse particles of a carrier together with fine particles of the drug(s), optionally together with small particles of carrier/diluent, which combination is generally known as an ordered mixture. An alternative to such a formulation is to agglomerate the small particles of the drug(s) and the carrier/diluent to agglomerates.

Formoterol (as fumarate dihydrate) as well as a carbohydrate such as lactose (preferably as the monohydrate) are very stable compounds individually, but degradation products are formed when the two compounds are mixed. A mixture of formoterol fumarate dihydrate and lactose monohydrate can be regarded as a three component system composed of formoterol fumarate, lactose and water. By sorption of water a saturated aqueous lactose solution is formed at the surface of the powder mixture. A certain amount of formoterol fumarate dissolves in this aqueous solution and is thereby susceptible to degradation. Therefore, the relative humidity, as well as the storage temperature, will influence the stability of the powder mixture.

When adding a third ingredient in the mixture the formation of degradation products would be expected to be higher due to the complexity and the possibility for many degradation processes. It would therefore be desirable to develop a formulation with good stability in spite of the complex mixture of compounds having reactive chemical functions such as an amine (formoterol), formamide (formoterol), carbohydrate (e.g. lactose) and a keto function (glucocorticosteroid). The presence of hydrates (formoterol fumarate dihydrate, lactose monohydrate) will make it even more complex.

DESCRIPTION OF THE INVENTION

In accordance with the present invention, there is provided a pharmaceutical composition in the solid state comprising, in admixture, a first active ingredient which is micronised formoterol or an enantiomer thereof, a second active ingredient which is a micronised glucocorticosteroid and a carrier or diluent, the composition having a high storage stability.

By the term "high storage stability" is meant that the decomposition of formoterol in the formulation will be less than 10% when-stored in open dishes at 40^oC. and 75% relative humidity for 6 months when the content of formoterol is less than about 1.0% (w/w), preferably less than 0.8% (w/w) and most preferably less than about 0.6% (w/w) in the formulation or, when stored in a dry powder device, a decomposition of less than about 2.5% under the same conditions.

The formulations having the desired stability are prepared using a novel process which involves:

1. preparing a mixture of micronised first active ingredient and micronised carrier/diluent

2. optionally adding further micronised carrier/diluent to the mixture

3. addition and mixing of pre-micronised hydrophobic second active ingredient, the second active ingredient being optionally pre-mixed with micronised carrier/diluent, and

4. either subjecting the mixture to agglomeration and spheronisation, or adding coarse carrier/diluent.

The first active ingredient and carrier/diluent can be prepared according to step 1 by micronising the two components together or each can be micronised individually and then combined to give a micronised mixture. Preferably the two components are mixed together and then micronised.

Preferably at step 3 the pre-micronised hydrophobic second active ingredient is added alone, ie in the absence of further micronised carrier/diluent.

Preferably step 4 involves subjecting the mixture to agglomeration and spheronisation.

By "micronised" is meant milling to give the a desired particle size or obtaining a desired particle size by any other means for producing small particles such as direct precipitation.

Optionally the mixture/ingredients can be conditioned at any suitable stage of the process, such as between steps 1 and 2, and/or the further pre-micronised carrier/diluent can be conditioned prior to addition at step 2, and/or the further pre-micronised carrier/diluent can be conditioned prior to addition at step 3, and/or the mixture can be conditioned between the agglomeration and spheronisation in step 4.

Conditioning can be carried out according to the procedures described in WO 95/05805 or by selecting the process parameters such as relative humidity in such a way that the final product when submitted to water vapour gives off heat of less than 1.2 joules per gram for the particles having a mean particle size of less than 10 .mu.m as described and measured in U.S. Pat. No. 5,874,063.

The invention therefore provides a pharmaceutical formulation in the solid state comprising, in admixture, a first active ingredient which is micronised formoterol or an enantiomer thereof, a second active ingredient which is a micronised glucocorticosteroid and a carrier/diluent and having a high storage stability characterised in that the formulation is prepared by micronisation of the first active ingredient and carrier/diluent, optionally followed by mixing pre-micronised coarser carrier/diluent, mixing with micronised hydrophobic second active ingredient, and finally either subjecting the mixture to agglomeration and spheronisation or adding coarse carrier/diluent.

The formoterol can be in the form of a mixture of enantiomers. Preferably the formoterol is in the form of a single enantiomer, preferably the R;R enantiomer. The formoterol can be in the form of the free base, salt or solvate, or a solvate of a salt, preferably the formoterol is in the form of its fumarate dihydrate salt. Other suitable physiologically salts include chloride, bromide, sulphate, phosphate, maleate, tartrate, citrate, benzoate, 4-methoxybenzoate, 2- or 4-hydroxybenzoate, 4-chlorobenzoate, p-toluenesulphonate, benzenesulphonate, ascorbate, acetate, succinate, lactate, glutarate, gluconate, tricaballate, hydroxynapaphthalenecarboxylate or oleate.

Preferably the second active ingredient is a micronised glucocorticosteroid such as budesonide, fluticasone propionate, mometasone furoate, ciclesonide and epimers, esters, salts and solvates of these compounds. More preferably the second active ingredient is budesonide or an epimer thereof, most preferably the 22R-epimer of budesonide.

Preferably the carrier is a carbohydrate having a high storage stability, preferably a reducing carbohydrate such as lactose, glucose, galactose, mannose, xylose, maltose, cellobiose, mellibiose, maltotriose (e.g. as monohydrate). More preferably the carrier is lactose.

As used herein the term micronised carrier/diluent refers to carrier/diluent having a mean particle size of less than about 25 .mu.m, preferably less than about 10 .mu.m, more preferable less than about 5 .mu.m. The micronised carrier can be produced using processes known in the art such as micronisation or direct precipitation. The term coarse carrier/diluent refers to carrier/diluent having a mean particle size of greater than about 25 .mu.m.

As used herein the term micronised first active ingredient or micronised second active ingredient means active ingredient having a mean particle size of less than about 10 .mu.m, preferably less than about 5 .mu.m.

The pharmaceutical compositions according to the invention can be used for the treatment or prophylaxis of a respiratory disorder, in particular the treatment or prophylaxis of asthma, rhinitis or COPD.

In a further aspect the invention provides a method of treating a respiratory disorder, in particular asthma, rhinitis or COPD, in a mammal which comprises administering to a patient a pharmaceutical composition as herein defined.

The compositions of the invention can be inhaled from a nebulizer, from a pressurized metered dose inhaler or as a dry powder from a dry powder inhaler e.g. multidose reservoir systems from AstraZeneca (Turbuhaler.RTM.) or Schering-Plough or from a dry powder inhaler utilizing gelatine, plastic or other capsules, cartridges or blister packs. Doses will be dependent on the severity of the disease and the type of patient.

Claim 1 of 7 Claims

What is claimed is:

1. A method of manufacturing a pharmaceutical composition that includes, in admixture, a first active ingredient which is micronised formoterol optionally in the form of a salt or solvate of a salt, a second active ingredient which is micronised glucocorticosteroid, and a pharmaceutically acceptable carner/diluent, the method comprising:

(a) preparing a mixture of the first active ingredient and a first portion of the carrier/diluent, both being in micronized form;

(b) adding the second active ingredient in pre-micronized form to the mixture of step (a) and mixing; and

(c) subsequent to step (b), adding a second portion of the carrier/diluent, in coarse form, to form a composition that is an ordered mixture.

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