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Title:  Swallowing-assistive drink
United States Patent: 
RE39,125
Issued: 
June 13, 2006

Inventors:
 Fukui; Atsuko (Yotsukaido, JP); Nakajima; Masanori (Chiba, JP); Kamijima; Takashi (Ina, JP); Ohta; Mika (Nagano, JP)
Assignee: 
Ryukakusan Co. LTD (JP)
Appl. No.:  643313
Filed: 
August 18, 2003


 

Executive MBA in Pharmaceutical Management, U. Colorado


Abstract

To provide a swallowing-assistive drink for medicines that improves swallowing various medicines, is convenient and substitutable with ordinary drinking water, and does not disturb the efficacy of medicines and a swallowing method.A swallowing-assistive drink for helping swallowing medicines that contains water and an adhesive paste, forming a viscous liquid or a gelatinoid. If the drink is viscous liquid, the viscosity is 1,000-25,000 cP at 20.degree. C., and if the drink is gelatinous, jelly gel strength is 10-100 g/cm.sup.2 at 20.degree. C.

BRIEF SUMMARY OF THE INVENTION

Objects of the Invention

The present invention has been conducted considering these problems of prior arts. An object of the present invention is to provide a swallowing-assistive drink for medicines that improves swallowing various medicines, being convenient and substitutable for ordinary water, moreover, not disturbing the efficacy of medicines, and a swallowing method.

SUMMARY OF THE INVENTION

The present inventors made various studies on a drink that facilitates swallowing medicines orally taken in order to solve the problems described above, formed that the above problems could be solved by mixing a specific adhesive paste with water and accomplished the present invention.

In the words, a swallowing-assistive drink of the present invention is an assistive- drink to facilitate swallowing medicines characterized in that it contains water and an adhesive paste to make viscous liquid or gelatinoid.

In addition, a swallowing method of the present invention is characterized by taking medicines together with the swallowing-assistive drink as mentioned above.

Operation

The swallowing-assistive drink of the present invention has an appropriate jelly gel strength or viscosity.

Accordingly, patients who have difficulty in swallowing medicines because of infirmity or various diseases besides healthy people can easily swallow various medicines by use of the present inventive swallowing-assistive drink without affecting the efficacy of the medicines.

Further, the swallowing-assistive drink of the present invention also has a function of enwrapping various kinds of medicines. Therefore, in those who have declined contractive strength of the muscle around the throat or stricture of the esophagus owing to the muscle strain, the feeling of the foreign substance can be reduced, leading to swallowing without choking, by use of the swallowing-assistive drink.

Specifically, owing to this enwrapping-function, highly water-soluble powder is enwrapped securely and hardly eluted at room temperature; as for solid formulations, the number of the medicine at a dose can be increased.

Further, such enwrapping-function makes medicine-masking possible. For example, the present swallowing-assistive drink functions as a bitter-taste mask, being convenient for infants or the like to take medicines.

Furthermore, in spite of having the enwrapping-function described above, the present swallowing-assistive drink neither affects on disintegration or dissolution of medicines nor causes interaction with medicines because a major ingredient of the drink is water; therefore, it does not disturb therapeutic effects of various medicines.

Moreover, the present swallowing-assistive drink is a low-calorie and non-sugar drink not affecting insulin metabolism; so that it can be also used safely in diabetic patients and it hardly causes caries even when using just before bedtime.

In addition, since the present swallowing-assistive drink is a simple drink containing water and an adhesive paste as essential components with excellent stability, it is easy to carry it if it is filled in a small container or the like, being convenient when patients go out.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

The swallowing-assistive drink of the present invention is illustrated in detail as follows.

As mentioned above, the swallowing-assistive drink contains water and an adhesive paste.

According to the present invention, water suitable for drinking is sufficient as water component and tapwater, various types of ion-exchange water, purified water or the like can be mentioned.

An adhesive paste may be any substance that can be mixed with water almost homogeneously to give viscosity or facilitate gelation. Specifically the following can be mentioned: agar, carrageenan, gellan gum, furcellaran, gelatin, pectin, curdlan, locust bean gum, tara gum, guar gum, xanthan gum, arginic acid, arginates, azotobacter vinelandi gum, cassia gum, psyllium seed gum, tamarind gum, CMCNa (carboxymethylcellulose Na), CMCCa, whey protein, starch or modified starch and their optional mixtures.

The swallowing-assistive drink of the present invention is a mixture of water and an adhesive paste as mentioned above, and takes forms of viscous liquid to gelatinoid at room temperature. Specifically, the viscosity at 20.degree. C. is preferably 1,000-25,000 cP if it is a viscous liquid, and the jelly gel strength at 20.degree. C. is preferably 10-100 g/cm.sup.2 if it is a gelatinoid.

If the jelly gel strength is less than 10 g/cm.sup.2 or the viscosity is less than 1,000 cP, misswallowing is apt to occur in swallowing medicines. On the other hand, if the jelly gel strength exceeds 100 g/cm.sup.2 or the viscosity exceeds 25,000 cP, swallowing becomes difficult for those who have difficulty in swallowing. Thus both cases are unpreferable.

Further, the content of the adhesive paste described above can be optionally selected considering the types of adhesive paste and the viscosity range described above, and may be typically 0.1-5.0 wt % to the total amount of the swallowing-assistive drink.

Water may be typically account for 80.0-99.9 wt %.

In addition, the swallowing-assistive drink of the present invention may contain additives such as gelation accelerators and sugars for a source of nutrition besides essential components, water and an adhesive paste, as long as it exhibits an effect of swallowing improvement which the present invention is intended.

For example, 0.2-2.0 wt % citric acid, and 0.1-0.2 wt % trisodium citrate can be added as a gelation accelerator, and 8-10 wt % sugars, such as mannitol, erythritol and glucose, can be added. As for sugars, those which diabetic patients can take are preferable. Further, 0.2-0.5 wt % dextrin may be added as a gelation adjuvant.

Next, a preparation method for the swallowing-assistive drink is illustrated.

The swallowing-assistive drink of the present invention can be obtained by dissolving an appropriate adhesive paste in an appropriate amount of heating water followed by addition of a gelation accelerator, a gelation enhancer, sugars, and other additives with dissolving by heating and stirring.

Dissolution temperature can optionally be altered, typically 80-100.degree. C. when dissolving by heating.

Further, the swallowing-assistive drink obtained as mentioned above can be taken together with various medicines: after keeping medicines in a mouth, the swallowing-assistive drink maybe poured into the mouth instead of water and swallowed together with the medicines or after premixing of the medicines with the swallowing-assistive drink, the obtained mixture (liquid) may be poured into the mouth and swallowed.

As mentioned above, the swallowing-assistive drink of the present invention is applied to various kinds of medicines, preferably applied especially for the medicines which have been considered difficult to be swallowed.

Medicines having such difficulty in being swallowed, are tablets having a diameter exceeding 10 mm and capsules having a size larger than No. 1. According to the present swallowing-assistive drink, even such tablets and capsules can be smoothly swallowed because they are enwrapped by the present swallowing-assistive drink having appropriate viscosity or the like as mentioned above.

Further, because granules and powders are stuck between false teeth and on a mucous membrane in the mouth or entered in the trachea, swallowing these often becomes difficult. By using the swallowing-assistive drink of the present invention, even such granule and powder formulations can be readily swallowed because the granules or the like are enwrapped with the present swallowing-assistive drink to prevent sticking in the mouth or the like.

Also, after use, the swallowing-assistive drink gives almost no remnant feeling in the mouth such as that given by soft drinks, but it leaves a light aftertaste. Therefore, it can be used preferably especially by false teeth users.

In addition, as for medicines having strong odors or bitter tastes, the dislike to the smells or bitter tastes sometimes leads to difficulty in swallowing. Even such medicines can be readily swallowed because of being enwrapped and masked by the present swallowing-assistive drink.

Besides, even the powder formulation in this case is prevented from being stuck in the mouth or the like as mentioned above, therefore it gives no problem of leaving unpleasant smells or bitter tastes.

Moreover, using the present swallowing-assistive drink makes it easier to take solid and powder formulations in mixture, which has been known to be difficult in swallowing.
 


Claim 1 of 24 Claims

1. A swallowing-assistive drink for assisting an individual in swallowing a medication, the swallowing-assistive drink comprising: water and an adhesive paste which form a viscous liquid having a viscosity in the range of from 1,000-25,000 cP at 20.degree. C.; and a medicine enwrapped in the viscous liquid; wherein said swallowing-assistive drink has been packaged in a prepared form in the absence of a medication prior to enwrapping the medicine.

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If you want to learn more about this patent, please go directly to the U.S. Patent and Trademark Office Web site to access the full patent.

 

 

     
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