United States Patent: RE39,125
Issued: June 13, 2006
Inventors: Fukui; Atsuko (Yotsukaido,
JP); Nakajima; Masanori (Chiba, JP); Kamijima; Takashi (Ina, JP); Ohta;
Mika (Nagano, JP)
Assignee: Ryukakusan Co.
Filed: August 18, 2003
Executive MBA in Pharmaceutical Management, U. Colorado
To provide a swallowing-assistive drink
for medicines that improves swallowing various medicines, is convenient
and substitutable with ordinary drinking water, and does not disturb the
efficacy of medicines and a swallowing method.A swallowing-assistive drink
for helping swallowing medicines that contains water and an adhesive
paste, forming a viscous liquid or a gelatinoid. If the drink is viscous
liquid, the viscosity is 1,000-25,000 cP at 20.degree. C., and if the
drink is gelatinous, jelly gel strength is 10-100 g/cm.sup.2 at 20.degree.
BRIEF SUMMARY OF THE
Objects of the Invention
The present invention has been conducted considering these problems of
prior arts. An object of the present invention is to provide a
swallowing-assistive drink for medicines that improves swallowing various
medicines, being convenient and substitutable for ordinary water,
moreover, not disturbing the efficacy of medicines, and a swallowing
SUMMARY OF THE
The present inventors made various
studies on a drink that facilitates swallowing medicines orally taken in
order to solve the problems described above, formed that the above
problems could be solved by mixing a specific adhesive paste with water
and accomplished the present invention.
In the words, a swallowing-assistive drink of the present invention is an
assistive- drink to facilitate swallowing medicines characterized in that
it contains water and an adhesive paste to make viscous liquid or
In addition, a swallowing method of the present invention is characterized
by taking medicines together with the swallowing-assistive drink as
The swallowing-assistive drink of the present invention has an appropriate
jelly gel strength or viscosity.
Accordingly, patients who have difficulty in swallowing medicines because
of infirmity or various diseases besides healthy people can easily swallow
various medicines by use of the present inventive swallowing-assistive
drink without affecting the efficacy of the medicines.
Further, the swallowing-assistive drink of the present invention also has
a function of enwrapping various kinds of medicines. Therefore, in those
who have declined contractive strength of the muscle around the throat or
stricture of the esophagus owing to the muscle strain, the feeling of the
foreign substance can be reduced, leading to swallowing without choking,
by use of the swallowing-assistive drink.
Specifically, owing to this enwrapping-function, highly water-soluble
powder is enwrapped securely and hardly eluted at room temperature; as for
solid formulations, the number of the medicine at a dose can be increased.
Further, such enwrapping-function makes medicine-masking possible. For
example, the present swallowing-assistive drink functions as a
bitter-taste mask, being convenient for infants or the like to take
Furthermore, in spite of having the enwrapping-function described above,
the present swallowing-assistive drink neither affects on disintegration
or dissolution of medicines nor causes interaction with medicines because
a major ingredient of the drink is water; therefore, it does not disturb
therapeutic effects of various medicines.
Moreover, the present swallowing-assistive drink is a low-calorie and
non-sugar drink not affecting insulin metabolism; so that it can be also
used safely in diabetic patients and it hardly causes caries even when
using just before bedtime.
In addition, since the present swallowing-assistive drink is a simple
drink containing water and an adhesive paste as essential components with
excellent stability, it is easy to carry it if it is filled in a small
container or the like, being convenient when patients go out.
OF THE PREFERRED EMBODIMENTS
The swallowing-assistive drink of the
present invention is illustrated in detail as follows.
As mentioned above, the swallowing-assistive drink contains water and an
According to the present invention, water suitable for drinking is
sufficient as water component and tapwater, various types of ion-exchange
water, purified water or the like can be mentioned.
An adhesive paste may be any substance that can be mixed with water almost
homogeneously to give viscosity or facilitate gelation. Specifically the
following can be mentioned: agar, carrageenan, gellan gum, furcellaran,
gelatin, pectin, curdlan, locust bean gum, tara gum, guar gum, xanthan
gum, arginic acid, arginates, azotobacter vinelandi gum, cassia gum,
psyllium seed gum, tamarind gum, CMCNa (carboxymethylcellulose Na), CMCCa,
whey protein, starch or modified starch and their optional mixtures.
The swallowing-assistive drink of the present invention is a mixture of
water and an adhesive paste as mentioned above, and takes forms of viscous
liquid to gelatinoid at room temperature. Specifically, the viscosity at
20.degree. C. is preferably 1,000-25,000 cP if it is a viscous liquid, and
the jelly gel strength at 20.degree. C. is preferably 10-100 g/cm.sup.2 if
it is a gelatinoid.
If the jelly gel strength is less than 10 g/cm.sup.2 or the viscosity is
less than 1,000 cP, misswallowing is apt to occur in swallowing medicines.
On the other hand, if the jelly gel strength exceeds 100 g/cm.sup.2 or the
viscosity exceeds 25,000 cP, swallowing becomes difficult for those who
have difficulty in swallowing. Thus both cases are unpreferable.
Further, the content of the adhesive paste described above can be
optionally selected considering the types of adhesive paste and the
viscosity range described above, and may be typically 0.1-5.0 wt % to the
total amount of the swallowing-assistive drink.
Water may be typically account for 80.0-99.9 wt %.
In addition, the swallowing-assistive drink of the present invention may
contain additives such as gelation accelerators and sugars for a source of
nutrition besides essential components, water and an adhesive paste, as
long as it exhibits an effect of swallowing improvement which the present
invention is intended.
For example, 0.2-2.0 wt % citric acid, and 0.1-0.2 wt % trisodium citrate
can be added as a gelation accelerator, and 8-10 wt % sugars, such as
mannitol, erythritol and glucose, can be added. As for sugars, those which
diabetic patients can take are preferable. Further, 0.2-0.5 wt % dextrin
may be added as a gelation adjuvant.
Next, a preparation method for the swallowing-assistive drink is
The swallowing-assistive drink of the present invention can be obtained by
dissolving an appropriate adhesive paste in an appropriate amount of
heating water followed by addition of a gelation accelerator, a gelation
enhancer, sugars, and other additives with dissolving by heating and
Dissolution temperature can optionally be altered, typically
80-100.degree. C. when dissolving by heating.
Further, the swallowing-assistive drink obtained as mentioned above can be
taken together with various medicines: after keeping medicines in a mouth,
the swallowing-assistive drink maybe poured into the mouth instead of
water and swallowed together with the medicines or after premixing of the
medicines with the swallowing-assistive drink, the obtained mixture
(liquid) may be poured into the mouth and swallowed.
As mentioned above, the swallowing-assistive drink of the present
invention is applied to various kinds of medicines, preferably applied
especially for the medicines which have been considered difficult to be
Medicines having such difficulty in being swallowed, are tablets having a
diameter exceeding 10 mm and capsules having a size larger than No. 1.
According to the present swallowing-assistive drink, even such tablets and
capsules can be smoothly swallowed because they are enwrapped by the
present swallowing-assistive drink having appropriate viscosity or the
like as mentioned above.
Further, because granules and powders are stuck between false teeth and on
a mucous membrane in the mouth or entered in the trachea, swallowing these
often becomes difficult. By using the swallowing-assistive drink of the
present invention, even such granule and powder formulations can be
readily swallowed because the granules or the like are enwrapped with the
present swallowing-assistive drink to prevent sticking in the mouth or the
Also, after use, the swallowing-assistive drink gives almost no remnant
feeling in the mouth such as that given by soft drinks, but it leaves a
light aftertaste. Therefore, it can be used preferably especially by false
In addition, as for medicines having strong odors or bitter tastes, the
dislike to the smells or bitter tastes sometimes leads to difficulty in
swallowing. Even such medicines can be readily swallowed because of being
enwrapped and masked by the present swallowing-assistive drink.
Besides, even the powder formulation in this case is prevented from being
stuck in the mouth or the like as mentioned above, therefore it gives no
problem of leaving unpleasant smells or bitter tastes.
Moreover, using the present swallowing-assistive drink makes it easier to
take solid and powder formulations in mixture, which has been known to be
difficult in swallowing.
Claim 1 of 24 Claims
1. A swallowing-assistive
drink for assisting an individual in swallowing a medication, the
swallowing-assistive drink comprising: water and an adhesive paste which
form a viscous liquid having a viscosity in the range of from 1,000-25,000
cP at 20.degree. C.; and a medicine enwrapped in the viscous liquid; wherein
said swallowing-assistive drink has been packaged in a prepared form in the
absence of a medication prior to enwrapping the medicine.
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